Daniel S. Peeper
Netherlands Cancer Institute
166 Papers
587 Citations
Daniel S. Peeper is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Biology & Melanoma. The author has an hindex of 49, co-authored 139 publications. Previous affiliations of Daniel S. Peeper include Leiden University & Harvard University.
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Papers
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Chrysiis Michaloglou,Liesbeth C.W. Vredeveld,Maria S. Soengas,Christophe Denoyelle,Thomas Kuilman,Chantal M.A.M. van der Horst,Donne Majoor,Jerry W. Shay,Wolter J. Mooi,Daniel S. Peeper +9 more
TL;DR: It is shown that sustained BRAFV600E expression in human melanocytes induces cell cycle arrest, which is accompanied by the induction of both p16INK4a and senescence-associated acidic β-galactosidase (SA-β-Gal) activity, a commonly usedsenescence marker.
The essence of senescence
TL;DR: The various features of cellular senescence are reviewed and their contribution to tumor suppression is discussed and the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo are highlighted.
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink,Sangeetha M. Reddy,Jianjun Gao,Shaojun Zhang,Rafet Basar,Rohit Thakur,Keren Yizhak,Moshe Sade-Feldman,Moshe Sade-Feldman,Jorge Blando,Guangchun Han,Vancheswaran Gopalakrishnan,Yuanxin Xi,Hao Zhao,Rodabe N. Amaria,Hussein Abdul-Hassan Tawbi,Alex P. Cogdill,Wenbin Liu,Valerie S. LeBleu,Fernanda G. Kugeratski,Sapna Pradyuman Patel,Michael A. Davies,Patrick Hwu,Jeffrey E. Lee,Jeffrey E. Gershenwald,Anthony Lucci,Reetakshi Arora,Scott E. Woodman,Emily Z. Keung,Pierre Olivier Gaudreau,Alexandre Reuben,Christine N. Spencer,Elizabeth M. Burton,Lauren E. Haydu,Alexander J. Lazar,Roberta Zapassodi,Courtney W. Hudgens,Deborah A. Ledesma,SuFey Ong,Michael Bailey,Sarah Warren,Disha Rao,Oscar Krijgsman,Elisa A. Rozeman,Daniel S. Peeper,Christian U. Blank,Ton N. Schumacher,Lisa H. Butterfield,Monika A. Zelazowska,Kevin M. McBride,Raghu Kalluri,James P. Allison,Florent Petitprez,Florent Petitprez,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Nir Hacohen,Nir Hacohen,Katayoun Rezvani,Padmanee Sharma,Michael T. Tetzlaff,Linghua Wang,Jennifer A. Wargo +64 more
TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Thomas Kuilman,Chrysiis Michaloglou,Liesbeth C.W. Vredeveld,Sirith Douma,Remco van Doorn,Christophe Desmet,Lucien A. Aarden,Wolter J. Mooi,Daniel S. Peeper +8 more
TL;DR: A model is proposed in which the context-dependent cytostatic and promitogenic functions of specific interleukins contribute to connect senescence with an inflammatory phenotype and cancer.
2K
The human tumor microbiome is composed of tumor type–specific intracellular bacteria
Deborah Nejman,Ilana Livyatan,Garold Fuks,Nancy Gavert,Yaara Zwang,Leore T. Geller,Aviva Rotter-Maskowitz,Roi Weiser,Roi Weiser,Giuseppe Mallel,Elinor Gigi,Arnon Meltser,Gavin M. Douglas,Iris Kamer,Vancheswaran Gopalakrishnan,Tali Dadosh,Smadar Levin-Zaidman,Sofia Avnet,Tehila Atlan,Zachary A. Cooper,Reetakshi Arora,Alexandria P. Cogdill,Abdul Wadud Khan,Gabriel Ologun,Yuval Bussi,Adina Weinberger,Maya Lotan-Pompan,Ofra Golani,Gili Perry,Merav Rokah,Keren Bahar-Shany,Elisa A. Rozeman,Christian U. Blank,Anat Ronai,Ron Shaoul,Amnon Amit,Amnon Amit,Tatiana Dorfman,Ran Kremer,Zvi R. Cohen,Zvi R. Cohen,Sagi Harnof,Sagi Harnof,Tali Siegal,Einav Yehuda-Shnaidman,Einav Nili Gal-Yam,Hagit Shapira,Nicola Baldini,Morgan G. I. Langille,Alon Ben-Nun,Alon Ben-Nun,Bella Kaufman,Bella Kaufman,Aviram Nissan,Talia Golan,Talia Golan,Maya Dadiani,Keren Levanon,Keren Levanon,Jair Bar,Jair Bar,Shlomit Yust-Katz,Shlomit Yust-Katz,Iris Barshack,Iris Barshack,Daniel S. Peeper,Dan J. Raz,Eran Segal,Jennifer A. Wargo,Judith Sandbank,Noam Shental,Ravid Straussman +71 more
TL;DR: A comprehensive analysis of the tumor microbiome was undertaken, studying 1526 tumors and their adjacent normal tissues across seven cancer types, finding that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome.
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