Daniel S. Asker
King's College London
6 Papers
74 Citations
Daniel S. Asker is an academic researcher from King's College London. The author has contributed to research in topics: Taurine & Steatosis. The author has an hindex of 6, co-authored 6 publications.
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Papers
Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats.
TL;DR: Thesein vivo findings demonstrate for the first time that hepatic steatosis and lipid peroxidation, occurring as a result of chronic alcohol consumption, can be ameliorated by administration of taurine to rats.
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Ethionine toxicity in vitro: the correlation of data from rat hepatocyte suspensions and monolayers with in vivo observations.
Catherine J. Waterfield,Carl Westmoreland,Daniel S. Asker,Janice C. Murdock,Elisabeth George,John A. Timbrell +5 more
TL;DR: H hepatocyte suspensions were able to mimic the early biochemical effects of ethionine in vivo and some effects on urea synthesis, but monolayer cultures appeared to be less sensitive to the toxicity of eth ionine, however, neither in vitro system was able to model the effects of Ethionine on the accumulation of triglycerides in vivo.
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The effect of taurine depletion by β-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats
TL;DR: In vivo findings demonstrate for the first time that animals treated with beta-alanine may be more susceptible to ethanol-induced hepatic dysfunction, possibly as a result of taurine depletion.
23
HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples: evidence for substrate inhibition kinetics.
TL;DR: A cell-free assay coupled with ion-pairing reverse-phase HPLC-UV detection of 1-methylnicotinamide which requires minimal sample manipulation, is linear over 2.5 orders of magnitude and demonstrates improved sensitivity over other previously published methods whilst lacking many of their drawbacks.
22
Is there a correlation between taurine levels and xenobiotic-induced perturbations in protein synthesis?: a study with tetracycline in rats.
TL;DR: The time course of the urinary elevation of taurine following treatment of rats with tetracycline and the use of taurus as a non-invasive marker of protein synthesis is discussed.
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