Daniel Roth
University of Warwick
12 Papers
4 Citations
Daniel Roth is an academic researcher from University of Warwick. The author has contributed to research in topics: Microtubule & Spindle apparatus. The author has an hindex of 8, co-authored 12 publications.
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Papers
Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain
Mark W. Richards,Laura O'Regan,Daniel Roth,Jessica M. Montgomery,Anne Straube,Andrew M. Fry,Richard Bayliss +6 more
TL;DR: In this article, crystal structures of the coiled-coils from EML2 and EML4 were determined, which describe the structural basis of both EML self-association and oncogenic EML 4-ALK activation.
A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation
TL;DR: It is shown that oMAP4 is expressed upon muscle cell differentiation and is the only MAP4 isoform essential for normal progression of the myogenic differentiation programme.
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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
Rozita Adib,Jessica M. Montgomery,Joseph Atherton,Laura O'Regan,Mark W. Richards,K.R. Straatman,Daniel Roth,Anne Straube,Richard Bayliss,Carolyn A. Moores,Andrew M. Fry +10 more
TL;DR: Findings reveal further insight into both the regulation of cell division and how NEKs promote tumor growth and support a model in which NEK6- and NEK7-dependent phosphorylation promotes the dissociation of EML4 from microtubules in mitosis in a manner that is required for efficient chromosome congression.
Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression
Andrew M. Fry,Rozita Adib,Jessica M. Montgomery,Joseph Atherton,Laura O'Regan,Mark W. Richards,K.R. Straatman,Daniel Roth,Anne Straube,Richard Bayliss,Carolyn A. Moores +10 more
TL;DR: The authors showed that EML4 is distributed as punctate foci along the microtubule lattice in interphase but exhibits reduced association with spindle microtubules in mitosis.