Daniel Romaker
Cleveland Clinic
11 Papers
73 Citations
Daniel Romaker is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Pronephros & Xenopus. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Daniel Romaker include University of Freiburg & University of Erlangen-Nuremberg.
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Papers
The protein kinase pUL97 of human cytomegalovirus interacts with and phosphorylates the DNA polymerase processivity factor pUL44.
Manfred Marschall,Martina Freitag,Patricia Suchy,Daniel Romaker,Regina Kupfer,Miriam Hanke,Thomas Stamminger +6 more
TL;DR: It is reported that pUL97 interacts with an essential component of the replication complex, the DNA polymerase processivity factor pUL44, and may be indirectly involved in viral genome replication by modifying the replication cofactor pUL 44.
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Increased expression of secreted frizzled-related protein 4 in polycystic kidneys.
Daniel Romaker,Michael Puetz,Sven Teschner,Johannes Donauer,Marcel Geyer,Peter Gerke,Brigitta Rumberger,Bernd Dworniczak,Petra Pennekamp,Björn Buchholz,Hartmut P. H. Neumann,Rajiv Kumar,Joachim Gloy,Kai-Uwe Eckardt,Gerd Walz +14 more
TL;DR: It is reported that secreted frizzled-related protein 4 (s FRP4) is upregulated in human ADPKD and in four different animal models of PKD, suggesting that sFRP4 expression is triggered by a common mechanism that underlies cyst formation.
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Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD
Wilfried Reichardt,Daniel Romaker,Anne Becker,Martin Buechert,Gerd Walz,Dominik von Elverfeldt +5 more
TL;DR: Using MRI, the cystic volume in a mouse model of PKD was monitored to assess the therapeutic effect of anticystic treatment, indicating that growth of the total renal volume in the untreated group was primarily due to the growth ofThe cysts, rather than the parenchyma.
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MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney.
TL;DR: It is shown for the first time, to the knowledge, that growth factors belonging to the Insulin growth factor family are critically important in establishing kidney size and that the strength of the signal is dependent on the presence of small noncoding RNAs termed microRNAs.
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The bigger the better: determining nephron size in kidney
TL;DR: Recent studies that highlight the early phases of kidney development as a critical juncture in establishing proximal tubule size are summarized.