Daniel R. Engel
University of Duisburg-Essen
60 Papers
339 Citations
Daniel R. Engel is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Biology & Innate immune system. The author has an hindex of 28, co-authored 51 publications. Previous affiliations of Daniel R. Engel include University of Bonn.
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Papers
Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy
Anika Klingberg,Anja Hasenberg,Isis Ludwig-Portugall,Anna Medyukhina,Linda Männ,Alexandra Brenzel,Daniel R. Engel,Marc Thilo Figge,Marc Thilo Figge,Christian Kurts,Matthias Gunzer +10 more
TL;DR: This approach delivers fundamental parameters of renal function, and because of its ease of use and speed, it is suitable for high-throughput analysis and could greatly facilitate studies of the effect of kidney diseases on whole-organ physiology.
Identification and Functional Characterization of Dendritic Cells in the Healthy Murine Kidney and in Experimental Glomerulonephritis
Thilo Krüger,Dirk Benke,Frank Eitner,Andreas Lang,Monika Wirtz,Emma E. Hamilton-Williams,Daniel R. Engel,Bernd Giese,Gerhard Müller-Newen,Jürgen Floege,Christian Kurts +10 more
TL;DR: These results are the first to identify and characterize renal CD11c(+) cells as dendritic cells as DC and to demonstrate marked changes in experimental glomerulonephritis.
251
Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium
Marzena Schiwon,Christina Weisheit,Lars Franken,Sebastian Gutweiler,Akanksha Dixit,Catherine Meyer-Schwesinger,Judith Mira Pohl,Nicholas J. Maurice,Stephanie Thiebes,Kristina Lorenz,Thomas Quast,Martin Fuhrmann,Georg Baumgarten,Martin J. Lohse,Ghislain Opdenakker,Jürgen Bernhagen,R Bucala,Ulf Panzer,Waldemar Kolanus,Hermann Josef Gröne,Natalio Garbi,Wolfgang Kastenmüller,Percy A. Knolle,Christian Kurts,Daniel R. Engel +24 more
TL;DR: Findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia, reminiscent of the licensing role of helper T cells in antiviral adaptive immunity.
243
Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.
Anja Hasenberg,Mike Hasenberg,Linda Männ,Franziska Neumann,Lars Borkenstein,Manuel Stecher,Andreas Kraus,Daniel R. Engel,Anika Klingberg,Pegah Seddigh,Zeinab Abdullah,Sabrina Klebow,Swen Engelmann,Annegret Reinhold,Sven Brandau,Michaela Seeling,Ari Waisman,Burkhart Schraven,Joachim R. Göthert,Falk Nimmerjahn,Matthias Gunzer +20 more
TL;DR: Modulating the neutrophil-specific locus Ly6G with a knock-in allele expressing Cre recombinase and the fluorescent protein tdTomato generated a mouse model termed Catchup that exhibits strong neutrophill specificity, suggesting a cell-intrinsic role for activating Fc receptors in neutrophils trafficking.
Dendritic Cells and Macrophages: Sentinels in the Kidney
TL;DR: This review summarizes the general functions and classification of dendritic cells and macrophages in the immune system and recapitulates why overlapping definitions and historically separate research have created controversy about their tasks.