Daniel Peltier
University of Michigan
33 Papers
25 Citations
Daniel Peltier is an academic researcher from University of Michigan. The author has contributed to research in topics: T cell & Medicine. The author has an hindex of 10, co-authored 23 publications.
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Papers
Microbial metabolite sensor GPR43 controls severity of experimental GVHD.
Hideaki Fujiwara,Melissa D. Docampo,Mary Riwes,Daniel Peltier,Tomomi Toubai,Israel Henig,S. Julia Wu,Stephanie Kim,Austin Taylor,Stuart Brabbs,Chen Liu,Cynthia Zajac,Katherine Oravecz-Wilson,Yaping Sun,Gabriel Núñez,John E. Levine,Marcel R.M. van den Brink,James L.M. Ferrara,Pavan Reddy +18 more
TL;DR: The metabolite sensor G-protein-coupled receptor 43 (GPR43) is important for attenuation of gastrointestinal GVHD in multiple clinically relevant murine models and is required for controlling disease pathology severity in the context of experimental models of GV HD.
Human Neuronal Cells Possess Functional Cytoplasmic and TLR-Mediated Innate Immune Pathways Influenced by Phosphatidylinositol-3 Kinase Signaling
TL;DR: The results indicate that human neuronal cells possess specific and functional PRR pathways essential for the effective induction of innate immune responses, and suggest that neurons can play an active role in defense against neurotropic pathogens.
miR-142 controls metabolic reprogramming that regulates dendritic cell activation.
Yaping Sun,Katherine Oravecz-Wilson,Sydney Bridges,Richard C. McEachin,Julia Wu,Stephanie Kim,Austin Taylor,Cynthia Zajac,Hideaki Fujiwara,Daniel Peltier,Thomas L. Saunders,Pavan Reddy +11 more
TL;DR: Findings show that miR-142 is central to the metabolic reprogramming that specifically favors glycolysis and immunogenic response by DCs.
Targeting the Gut Microbiome to Mitigate Immunotherapy-Induced Colitis in Cancer
Amy Chang,Jonathan L. Golob,Thomas M. Schmidt,Daniel Peltier,Christopher D. Lao,Muneesh Tewari +5 more
TL;DR: In this paper, the use of dietary prebiotics, which can be metabolized by bacteria to produce butyrate, can be an intriguing new investigational approach to prevent ICI-associated colitis and lead to improved patient outcomes.
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Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition.
Tomomi Toubai,Hideaki Fujiwara,Corinne Rossi,Mary Riwes,Hiroya Tamaki,Cynthia Zajac,Chen Liu,Anna V. Mathew,Jaeman Byun,Katherine Oravecz-Wilson,Ikuo Matsuda,Yaping Sun,Daniel Peltier,Julia Wu,Jiachen Chen,Sergey S. Seregin,Israel Henig,Stephanie Kim,Stuart Brabbs,Subramaniam Pennathur,Grace Y. Chen,Pavan Reddy +21 more
TL;DR: An unexpected, pathogenic role for host NLRP6 in gastrointestinal GVHD is unveiled that is independent of variations in the intestinal microbiome and in contrast to its well-appreciated microbiome-dependent protective role in intestinal colitis and tumorigenesis.
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