The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly 25,000 publications since 1930 (see FIGURE 1, as listed in PubMed), which revealed central roles for OXT and ...

/pdf/the-oxytocin-receptor-from-intracellular-signaling-to-3woxj4pz9l.pdf

The Oxytocin Receptor: From Intracellular Signaling to Behavior

The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain’s reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences.

http://science.sciencemag.org/content/sci/357/6358/1406.full.pdf

Gating of social reward by oxytocin in the ventral tegmental area.

Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing

Biased Oxytocinergic Modulation of Midbrain Dopamine Systems.

Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the physiological functions of Oxtrs in the hippocampus are not known. Here we demonstrate using genetic and pharmacological approaches that Oxtrs in the anterior dentate gyrus (aDG) and anterior CA2/CA3 (aCA2/CA3) of mice are necessary for discrimination of social, but not non-social, stimuli. Further, Oxtrs in aCA2/CA3 neurons recruit a population-based coding mechanism to mediate social stimuli discrimination. Optogenetic terminal-specific attenuation revealed a critical role for aCA2/CA3 outputs to posterior CA1 for discrimination of social stimuli. In contrast, aCA2/CA3 projections to aCA1 mediate discrimination of non-social stimuli. These studies identify a role for an aDG-CA2/CA3 axis of Oxtr expressing cells in discrimination of social stimuli and delineate a pathway relaying social memory computations in the anterior hippocampus to the posterior hippocampus to guide social recognition.

/pdf/hippocampal-oxytocin-receptors-are-necessary-for-40duivgnj4.pdf

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

https://www.cell.com/neuron/pdf/S0896-6273(15)00565-6.pdf

Oxytocin Mediates Entrainment of Sensory Stimuli to Social Cues of Opposing Valence

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Oxytocin Mediates Entrainment of Sensory Stimuli to Social Cues of Opposing Valence