Daniel M. Hayes
Memorial Sloan Kettering Cancer Center
2 Papers
Daniel M. Hayes is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Diuresis & Creatinine. The author has an hindex of 2, co-authored 2 publications.
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Papers
High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis.
Daniel M. Hayes,Esteban Cvitkovic,Robert B. Golbey,Ellen Scheiner,Lawrence Helson,Irwin H. Krakoff +5 more
TL;DR: A clinical trial was undertaken to improve the therapeutic index of cis‐plati‐num diammine dichloride with a concomitantly administered mannitol induced diuresis and CPDD administration, with Clinically significant responses in epidermoid carcinoma of the head and neck, adenocarcinomas of the ovary, and germ cell tumors of the testis.
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The renal pathology in clinical trials of cis-platinum (II) diamminedichloride
TL;DR: It is suggested that mannitol‐induced diuresis has considerably decreased the renal toxic damage of CPDD therapy in these patients.