Daniel M. Gorman
Schering-Plough
86 Papers
845 Citations
Daniel M. Gorman is an academic researcher from Schering-Plough. The author has contributed to research in topics: Nucleic acid & Cytokine. The author has an hindex of 29, co-authored 84 publications. Previous affiliations of Daniel M. Gorman include Merck & Co..
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Papers
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Daniel J. Cua,Jonathan P Sherlock,Yi Chen,Craig A. Murphy,Barbara L. Joyce,Brian W. P. Seymour,Linda Lucian,Wayne To,Sylvia Kwan,Tatyana Churakova,Sandra Zurawski,Maria T. Wiekowski,Sergio A. Lira,Sergio A. Lira,Daniel M. Gorman,Robert A. Kastelein,Jonathon D. Sedgwick +16 more
TL;DR: It is shown that the perceived central role for IL-12 in autoimmune inflammation, specifically in the brain, has been misinterpreted and that IL-23, and not IL- 12, is the critical factor in this response.
3.1K
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Birgit Oppmann,Robin Lesley,Bianca Blom,Jackie C. Timans,Yuming Xu,Brisdell Hunte,Felix Vega,Nancy Yu,Jing Wang,Komal Singh,Francesca Zonin,Elena Vaisberg,Tatyana Churakova,Man ru Liu,Daniel M. Gorman,Janet Wagner,Sandra Zurawski,Yong-Jun Liu,John S. Abrams,Kevin W. Moore,Donna Rennick,Rene de Waal-Malefyt,Charles H. Hannum,J. Fernando Bazan,Robert A. Kastelein +24 more
TL;DR: Human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells and induces strong proliferation of mouse memory T cells.
3K
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Vassili Soumelis,Pedro A. Reche,Holger Kanzler,Wei Yuan,Gina Edward,Bernhart Homey,Michel Gilliet,Steve Ho,Svetlana Antonenko,Annti Lauerma,Kathleen M. Smith,Daniel M. Gorman,Sandra Zurawski,Jon Abrams,Satish Menon,Terri McClanahan,Rene de Waal-Malefyt,Fernando Bazan,Robert A. Kastelein,Yong-Jun Liu +19 more
TL;DR: It is shown that human thymic stromal lymphopoietin (TSLP) potently activated CD11c+ dendritic cells (DCs) and induced production of the TH2-attracting chemokines TARC (thymus and activation-regulated chemokine) and MDC (macrophage-derivedChemokine; CCL22).
IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells
Stefan Pflanz,Jackie C. Timans,Jeanne Cheung,Rency Rosales,Holger Kanzler,Jonathan M. Gilbert,Linda Hibbert,Tatyana Churakova,Marilyn Travis,Elena Vaisberg,Wendy M. Blumenschein,Jeanine D. Mattson,Janet Wagner,Wayne To,Sandra Zurawski,Terrill K. McClanahan,Daniel M. Gorman,J. Fernando Bazan,Rene de Waal Malefyt,Donna Rennick,Robert A. Kastelein +20 more
TL;DR: A new heterodimeric cytokine termed IL-27 is described that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL- 12p35-related polypeptide and drives rapid clonal expansion of naive but not memory CD4(+) T cells.
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