Daniel Lüscher

TL;DR: It is found that the progress of plaque-to-pretzel maturation is regulated by agrin, and agrin cleavage at its proteolytic α- and β-sites by an as-yet-unspecified protease is characterized as a regulatory access for relieving the agrin-dependent constraint on endplate reorganization during NMJ maturation.

TL;DR: The combinatorial application of Foslipos(®) and hypericin as well as their 1:1 combination on two different head and neck squamous cell carcinoma cell lines shows that the combinatorsial application decrease photosensitizer toxicity, which can be advantageous in PDT treatments.

TL;DR: Examination of death pathways showed that hypericin‐mediated cell death was apoptotic, with mTHPC necrotic and the 1:1 mixture showed features of both, suggesting the application of photosensitizer mixtures with the features of reduced dark toxicity and combined apoptotic and nec rotic cell death may be beneficial in clinical PDT.

TL;DR: Site-specific mutations of the amino acids flanking the scissile bonds showed that cleavage is highly specific and requires a basic amino acid preceded by a glutamate residue on the N-terminal side of the scISSile bond, which argues for a unique substrate binding pocket of neurotrypsin.