Porous nanocellulose gels and foams: Breakthrough status in the development of scaffolds for tissue engineering

제약공업에서 정제를 성형시 사용하는 가장 중요한 첨가제 중의 하나인 미정질 셀룰로우스를 대상으로 하여 유성밀로 분쇄했을 때, 분쇄공정변수가 그것의 비표면적에 미치는 영향을 고찰하기 위하여 회귀분석을 하였다. 분쇄공정변수로서 독립변수인 시료장입량, 밀회전수 및 분쇄시간과 종속변수인 비표면적 사이에는 이차다항회귀곡선식이...

분쇄공정변수가 Microcrystalline cellulose의 비표면적에 미치는 영향

Sustainable cellulose and its derivatives for promising biomedical applications

When pursuing sustainable approaches to fabricate photonic structures, nature can be used as a source of inspiration for both the nanoarchitecture and the constituent materials. Although several biomaterials have been promised as suitable candidates for photonic materials and pigments, their fabrication processes have been limited to the small to medium-scale production of films. Here, the interfacial buckling of a kinetically arrested cellulose nanocrystal (CNC) suspension within an emulsified microdroplet is exploited to produce cellulosic photonic pigments using a scalable methodology. The controlled removal of water from the buckled microparticles allows for the inherent limitations of CNC self-assembly under spherical confinement to be overcome, resulting in vibrant red, green, and blue dispersions of photonic CNC pigments. The hierarchical structure of these pigments enables the production of coatings with angular independent colour, offering a consistent visual appearance across a wide range of viewing angles.

Cellulose Photonic Pigments

The quest for interesting properties and phenomena in liquid crystals toward their employment in nondisplay application is an intense and vibrant endeavor. Remarkable progress has recently been achieved with regard to liquid crystals in curved confined geometries, typically represented as enclosed spherical geometries and cylindrical geometries with an infinitely extended axial-symmetrical space. Liquid-crystal emulsion droplets and fibers are intriguing examples from these fields and have attracted considerable attention. It is especially noteworthy that the rapid development of microfluidics brings about new capabilities to generate complex soft microstructures composed of both thermotropic and lyotropic liquid crystals. This review attempts to outline the recent developments related to the liquid crystals in curved confined geometries by focusing on microfluidics-mediated approaches. We highlight a wealth of novel photonic applications and beyond and also offer perspectives on the challenges, opportunities, and new directions for future development in this emerging research area.

Liquid Crystals in Curved Confined Geometries: Microfluidics Bring New Capabilities for Photonic Applications and Beyond

Cellulose nanocrystals (CNCs) are rigid rodlike nanoparticles that are derived from natural cellulose. Their high surface area, mechanical strength, and noncytotoxicity have elicited interest in their use for various applications, including composite and construction materials, cosmetic, food, and biomedical products. However, few methods exist to control the morphology and dimensions of assembled CNC structures in the micrometer range. Here, we use water-in-oil droplet microfluidics to template uniform spherical CNC droplets in a nontoxic and sustainable manner. Subsequent evaporation of the water within the droplets promotes the chemical cross-linking of surface-modified CNCs, resulting in ultraporous and flexible micrometer-sized particles. Changing the size of the microfluidic channel or the concentration of the CNC suspension results in microparticles with tunable sizes. The microparticles swell in polar solvents, with larger swelling observed for microparticles fabricated from less-concentrated CNC ...

Green Templating of Ultraporous Cross-Linked Cellulose Nanocrystal Microparticles

Introduction:Gastrointestinal manifestations of systemic sclerosis affect up to 90% of patients, with symptoms including diarrhea and constipation. Small intestinal bacterial overgrowth is a condit...

https://journals.sagepub.com/doi/pdf/10.1177/23971983211032808

Fecal microbiome differs between patients with systemic sclerosis with and without small intestinal bacterial overgrowth

Introduction The coronavirus disease 2019 (COVID-19) pandemic has been unprecedented in recent history. The rapid global spread has demonstrated how the emergence of a novel pathogen necessitates new information to advise both healthcare systems and policy-makers. The directives for the management of COVID-19 have been limited to infection control measures and treatment of patients, which has left physicians and researchers alone to navigate the massive amount of research being published while searching for evidence-based strategies to care for patients. To tackle this barrier, we launched CovidReview.ca, an open-access, continually updated, online platform that screens available COVID-19 research to determine higher quality publications. This paper uses data from this review process to explore the activity and trends of COVID-19 research worldwide over time, while specifically looking at the types of studies being published. Materials and Methods The literature search was conducted on PubMed. Search terms included "COVID-19", "severe acute respiratory syndrome coronavirus 2", "coronavirus 19", "SARS-COV-2", and "2019-nCoV". All articles captured by this strategy were reviewed by a minimum of two reviewers and categorized by type of research, relevant medical specialties, and type of publication. Criteria were developed to allow for inclusion or exclusion to the website. Due to the volume of research, only a level 1 (title and abstract) screen was performed. Results The time period for the analysis was January 17, 2020, to May 10, 2020. The total number of papers captured by the search criteria was 10,685, of which 2,742 were included on the website and 7,943 were excluded. The greatest increase in the types of studies over the 16 weeks was narrative review/expert opinion papers followed by case series/reports. Meta-analyses, systematic reviews, and randomized controlled trials remained the least published types of studies. Conclusions The surge of research that accompanied the COVID-19 pandemic is unparalleled in recent years. From our analysis, it is clear that case reports and narrative reviews were the most widely published, particularly in the earlier days of this pandemic. Continued research that falls higher on the evidence pyramid and is more applicable to clinical settings is warranted.

/pdf/evaluating-trends-in-covid-19-research-activity-in-early-4dzhloq994.pdf

Evaluating Trends in COVID-19 Research Activity in Early 2020: The Creation and Utilization of a Novel Open-Access Database

Background: Undergraduate medical students seek as much information as possible as to how residency programs select candidates.  The Canadian Residency Matching Service (CaRMS) website is one of their primary sources of information. Students may be more competitive in the match if they know whether scholarly activity is used in the selection process by their preferred programs, as described on the CaRMS website..
Methods: For all 17 Canadian faculties of medicine, 2019 R1 entry internal medicine, family medicine and pediatrics program descriptions were reviewed on the CaRMS website looking for keywords related to scholarly activity.
Results: Forty-one percent of family medicine, 65% of internal medicine and 71% of pediatric programs explicitly stated having interest in applicants with scholarly experience. In Western Canada, 80% of internal medicine and 60% of pediatrics programs included scholarly activity in their CaRMS description of criteria considered in ranking applications. Similarly, in Ontario, 66% of internal medicine and 83% of pediatrics programs mentioned scholarly activity as a valuable quality. In Quebec 100% of family medicine and 50% of pediatrics programs include scholarly activity in their descriptions. Pediatrics and internal medicine programs (100%) in Atlantic Canada mentioned scholarly activities but neither of the two Atlantic Canada internal medicine programs mentioned scholarly activities.
Conclusion: Undergraduate medical students can use this project to prioritize extracurricular activities and scholarly work to be competitive for application to family medicine, internal medicine and pediatrics residency programs.

https://journalhosting.ucalgary.ca/index.php/cmej/article/download/69094/54195

Scholarly activity as a selection criterion in the Canadian Residency Matching Service (CaRMS): A review of published criteria by internal medicine, family medicine, and pediatrics programs.

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Green Templating of Ultraporous Cross-Linked Cellulose Nanocrystal Microparticles

Fecal microbiome differs between patients with systemic sclerosis with and without small intestinal bacterial overgrowth

Evaluating Trends in COVID-19 Research Activity in Early 2020: The Creation and Utilization of a Novel Open-Access Database

Scholarly activity as a selection criterion in the Canadian Residency Matching Service (CaRMS): A review of published criteria by internal medicine, family medicine, and pediatrics programs.