Daniel Larocque
Cedars-Sinai Medical Center
13 Papers
28 Citations
Daniel Larocque is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Adjuvant & Immune system. The author has an hindex of 6, co-authored 12 publications.
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Papers
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity.
Arnaud Didierlaurent,Sandra Morel,Laurence Lockman,Sandra L. Giannini,Michel Bisteau,Harald Carlsen,Anders Kielland,Olivier Vosters,Nathalie Vanderheyde,Francesca Schiavetti,Daniel Larocque,Marcelle Van Mechelen,Nathalie Garçon +12 more
TL;DR: Results support a model in which the addition of MPL to aluminum salt enhances the vaccine response by rapidly triggering a local cytokine response leading to an optimal activation of APCs, and support the favorable safety profile of AS04 adjuvanted vaccines.
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Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology
Daniel Larocque,Nicholas S. R. Sanderson,Nicholas S. R. Sanderson,Josee Bergeron,Josee Bergeron,Josee Bergeron,James F. Curtin,James F. Curtin,James F. Curtin,Joe Girton,Joe Girton,Mia Wibowo,Niyati Bondale,Niyati Bondale,Kurt M. Kroeger,Kurt M. Kroeger,Jieping Yang,Jieping Yang,Liliana M. Lacayo,Kevin C. Reyes,Catherine Farrokhi,Robert N. Pechnick,Robert N. Pechnick,Maria G. Castro,Maria G. Castro,Pedro R. Lowenstein,Pedro R. Lowenstein +26 more
TL;DR: Testing the prediction that expression of fms-like tyrosine kinase ligand 3 in the brain will recruit dendritic cells and induce a systemic immune response against exogenous influenza hemagglutinin in BALB/c mice demonstrates that Flt3L overcomes the brain's immune privilege, and supports the clinical development of Flt2L as an adjuvant to stimulate clinically effective immune responses against brain neo-antigens.
Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies.
Maxime Hallé,Pascale Tribout-Jover,Anne-Marie Lanteigne,Jonathan Boulais,Julien R. St-Jean,Rachel Jodoin,Marie-Pier Girouard,Florin Constantin,Annik Migneault,Frédéric Renaud,Arnaud Didierlaurent,Corey P. Mallett,David J. Burkhart,Anthony Pilorget,Remi Palmantier,Daniel Larocque +15 more
TL;DR: A new biomarker testing to follow amyloid clearance within the blood and a mechanism of Aβ uptake by peripheral monocytes in the context of active or passive immunization are highlighted, and novel approaches to investigate this phenomenon are developed.
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Patent
Novel Compositions and Adjuvants
Daniel Larocque,Martin Plante,Martin Gagne +2 more
- 04 Sep 2009
TL;DR: In this article, the authors proposed adjuvants with at least one lipoprotein, such as Lip, Lip fragments or Lip variants, where the lipidoprotein comprises at least a pentameric unit and at least two lipid moieties.
6
Patent
Compositions and uses thereof for the treatment or prevention of alzheimer's disease
Daniel Larocque,Remi Palmantier,Pascale Tribout-Jover +2 more
- 01 May 2012
TL;DR: In this article, compositions and methods comprising or using a combination of an adjuvant such as AS01B and an antigen such as a β-amyloid antigen are provided.
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