Daniel Klamer
University of Gothenburg
35 Papers
502 Citations
Daniel Klamer is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Phencyclidine & Prepulse inhibition. The author has an hindex of 19, co-authored 33 publications.
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Papers
Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice.
James M. Doherty,Virginia L. Masten,Susan B. Powell,Rebecca J. Ralph,Daniel Klamer,Malcolm J. Low,Mark A. Geyer +6 more
TL;DR: Uncovering neural mechanisms involved in PPI will further the understanding of substrates of sensorimotor gating and could lead to better therapeutics to treat complex cognitive disorders such as schizophrenia.
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The nitric oxide synthase inhibitor, L -NAME, blocks phencyclidine-induced disruption of prepulse inhibition in mice
TL;DR: The PCP-induced disruption of prepulse inhibition and the ability of L-NAME to block this effect in both rats and mice suggest that this is a general and not a species-specific effect.
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The neuronal selective nitric oxide synthase inhibitor, Nω-propyl-l-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice
TL;DR: It is concluded that the NOS-sensitive behavioural effects of Phencyclidine in rodents is dependent on neuronal NOS and that NO may play a role in the psychotomimetic effects of phencyclidine.
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Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms
TL;DR: The finding that PCP, MK-801 and d-AMP impair habituation in mice is consistent with the idea that these treatments model certain filter deficits seen in schizophrenic patients, and the present results suggest that NO is critically involved in these effects on habituation, whereas that of dopamine is less clear.
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Effects of phencyclidine on spatial learning and memory: Nitric oxide-dependent mechanisms
Caroline Wass,Trevor Archer,Erik Pålsson,Kim Fejgin,Daniel Klamer,Jörgen A. Engel,Lennart Svensson +6 more
TL;DR: PCP in a dose of 2 mg/kg disrupts spatial learning as estimated by prolonged search time to find platform during acquisition as well as the reference memory test as measured by less time spent in target quadrant during probe trial.
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