Daniel K. Fabian
European Bioinformatics Institute
28 Papers
169 Citations
Daniel K. Fabian is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 10, co-authored 25 publications. Previous affiliations of Daniel K. Fabian include University of Cambridge & University of Veterinary Medicine Vienna.
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Papers
Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster
TL;DR: Using diagnostic single nucleotide polymorphism (SNP) markers to estimate inversion frequencies from 28 whole-genome Pool-seq samples collected from 10 populations along the North American east coast provides strong evidence that inversion clines are maintained by spatially-and perhaps also temporally-varying selection.
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Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster.
Michael M. Magwire,Daniel K. Fabian,Hannah Schweyen,Chuan Cao,Ben Longdon,Florian Bayer,Francis M. Jiggins +6 more
TL;DR: The data suggest that selection for resistance to infectious disease can increase genetic variation by increasing the frequency of major-effect alleles, and this has resulted in a simple genetic basis to variation in virus resistance.
Common genetic associations between age-related diseases
Handan Melike Dönertaş,Daniel K. Fabian,Daniel K. Fabian,Matías Fuentealba Valenzuela,Matías Fuentealba Valenzuela,Linda Partridge,Janet M. Thornton +6 more
- 01 Apr 2021
TL;DR: It is found that diseases with the same onset profile are genetically more similar, suggesting a common etiology, and two of the four disease clusters showed an association with known aging-related genes, yet differed in functional enrichment and evolutionary profiles.
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Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa.
Daniel K. Fabian,Justin B. Lack,Vinayak Mathur,Christian Schlötterer,Paul S. Schmidt,John E. Pool,Thomas Flatt +6 more
TL;DR: The results suggest that geographic and/or climatic factors drive adaptive phenotypic differentiation among ancestral African populations and confirm the widely held notion that latitude and altitude represent parallel gradients.
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