Daniel K. Choo
University of Pennsylvania
6 Papers
15 Citations
Daniel K. Choo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: DNA vaccination & Immune system. The author has an hindex of 5, co-authored 6 publications.
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Papers
Synthetic DNA vaccine strategies against persistent viral infections.
TL;DR: Recent improvements to this synthetic platform are focused on in relation to their application in combating persistent virus infection.
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HIV-Mediated Phosphatidylinositol 3-Kinase/Serine–Threonine Kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of HIV-Specific CD8 T Cells
Karuppiah Muthumani,Devon J. Shedlock,Daniel K. Choo,Paolo Fagone,Omkar U. Kawalekar,Jonathan Goodman,Chaoran B. Bian,Aarti A. Ramanathan,Parikh Atman,Pablo Tebas,Michael A. Chattergoon,Andrew Y. Choo,David B. Weiner +12 more
TL;DR: A novel mechanism by which HIV exploits the immunosuppressive PD-1 pathway is identified and a new role for virus-infected cells in the local corruption of immune responses required for viral suppression is suggested.
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model
Jian Yan,Colleen Tingey,Randolph B. Lyde,T C Gorham,Daniel K. Choo,A Muthumani,Devin J.F. Myles,L P Weiner,Kimberly A. Kraynyak,Emma L. Reuschel,Terri H. Finkel,Jong J. Kim,Niranjan Y. Sardesai,Kenneth E. Ugen,Karuppiah Muthumani,DB Weiner +15 more
TL;DR: This novel synthetic DNA vaccine significantly reduced the melanoma tumor burden and increased survival in vivo, due likely, in part, to the facilitation of a change in the tumor microenvironment through MDSC suppression.
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DNA Vaccination in Immunotherapy of Cancer
TL;DR: Nucleic acid immunization has garnered much attention as a promising approach for cancer therapeutic development and many investigators were focusing on if such proteins implemented for such gene therapy experiments could be employed to express antigens to stimulate the immune system.
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This information is current as Independent of CD4 T Cell Help Longevity of CD8 T Cells That Are Partially Plasmid Results in Enhanced Function and Coimmunization with an Optimized IL-15
Thomas A. Waldmann,Jean D. Boyer,J. Joseph Kim,George N. Pavlakis,Yutaka Tamura,Maninder K. Sidhu,Mathura P. Ramanathan,Daniel K. Choo,Andrew Y. Choo,A. Kutzler,Tara M. Robinson +10 more
- 01 Jan 2013