Daniel Janitschke
Saarland University
21 Papers
27 Citations
Daniel Janitschke is an academic researcher from Saarland University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 12 publications.
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Papers
Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.
Marcus O. W. Grimm,Andrea Thiel,Anna A. Lauer,Jakob Winkler,Johannes Lehmann,Liesa Regner,Christopher Nelke,Daniel Janitschke,Céline Benoist,Olga Streidenberger,Hannah Stötzel,Kristina Endres,Christian Herr,Christoph Beisswenger,Heike S. Grimm,Robert Bals,Frank Lammert,Tobias Hartmann +17 more
TL;DR: Vitamin D and analogues decreased β-secretase activity, not only in mouse brains with mild vitamin D hypovitaminosis, but also in non-deficient mouse brains, suggesting that supplementation of vitamin D or vitamin D analogues might have beneficial effects in AD prevention.
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Methylxanthines and Neurodegenerative Diseases: An Update.
Daniel Janitschke,Anna A. Lauer,Cornel M Bachmann,Heike S. Grimm,Tobias Hartmann,Marcus O. W. Grimm +5 more
TL;DR: In this paper, the impact of methylxanthines in neurodegenerative diseases has been extensively studied and several new aspects have been elucidated, such as adenosine receptor antagonism, phosphodiesterase inhibition, effects on the cholinergic system, wnt signaling, histone deacetylase activation and gene regulation.
Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.
Daniel Janitschke,Christopher Nelke,Anna A. Lauer,Liesa Regner,Jakob Winkler,Andrea Thiel,Heike S. Grimm,Tobias Hartmann,Marcus Otto Walter Grimm +8 more
- 02 Nov 2019
TL;DR: All MTXs act via the pleiotropic mechanism resulting in decreased Aβ and show beneficial properties with respect to AD in neuroblastoma cells, suggesting thatMTXs should be integrated in a healthy diet rather than be used exclusively to treat or prevent AD.
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Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.
Marcus O. W. Grimm,Anna A. Lauer,Sven Grösgen,Andrea Thiel,Johannes Lehmann,Jakob Winkler,Daniel Janitschke,Christian Herr,Christoph Beisswenger,Robert Bals,Heike S. Grimm,Tobias Hartmann +11 more
TL;DR: The results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.
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Aspartame and Its Metabolites Cause Oxidative Stress and Mitochondrial and Lipid Alterations in SH-SY5Y Cells
L. V. Griebsch,E. L. Theiss,Daniel Janitschke,Vincent Konrad Johannes Erhardt,Tobias Erhardt,Elodie Christiane Haas,Konstantin Nicolas Kuppler,Juliane Radermacher,Oliver Walzer,Anna A. Lauer,Veronika Matschke,Tobias Hartmann,Marcus O. W. Grimm,Heike S. Grimm +13 more
TL;DR: In this article , the effects of aspartame on the brain metabolism were investigated in a human neuroblastoma cell line SH-SY5Y with either aspartic acid, phenylalanine, and methanol.
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