Daniel J. Silver
Case Western Reserve University
40 Papers
80 Citations
Daniel J. Silver is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Biology & Tumor microenvironment. The author has an hindex of 12, co-authored 22 publications. Previous affiliations of Daniel J. Silver include University of Florida & Cleveland Clinic.
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Papers
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
Florian A. Siebzehnrubl,Daniel J. Silver,Bugra Tugertimur,Loic P. Deleyrolle,Dorit Siebzehnrubl,Matthew R. Sarkisian,Kelly G. Devers,Antony T. Yachnis,Marius D. Kupper,Daniel Neal,Nancy H. Nabilsi,Michael P. Kladde,Oleg Suslov,Simone Brabletz,Thomas Brabletz,Brent A. Reynolds,Dennis A. Steindler +16 more
TL;DR: Evidence is provided that the transcription factor ZEB1 exerts simultaneous influence over invasion, chemoresistance and tumourigenesis in glioblastoma, and this regulator of epithelial‐mesenchymal transition orchestrates key features of cancer stem cells in malignant glioma.
385
Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner.
Defne Bayik,Defne Bayik,Yadi Zhou,Chihyun Park,Changjin Hong,Daniel Vail,Daniel J. Silver,Daniel J. Silver,Adam Lauko,Adam Lauko,Adam Lauko,Gustavo Roversi,Gustavo Roversi,Dionysios C. Watson,Alice Lo,Alice Lo,Tyler J. Alban,Tyler J. Alban,Tyler J. Alban,Mary McGraw,Mia Dahl Sørensen,Matthew M. Grabowski,Balint Otvos,Michael A. Vogelbaum,Craig Horbinski,Bjarne Winther Kristensen,Ahmad M. Khalil,Tae Hyun Hwang,Tae Hyun Hwang,Manmeet S. Ahluwalia,Manmeet S. Ahluwalia,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng,Justin D. Lathia,Justin D. Lathia +35 more
TL;DR: It is demonstrated that MDSC subsets differentially drive immune suppression in a sex-specific manner and can be leveraged for therapeutic intervention in GBM.
191
GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity
Dionysios C. Watson,Defne Bayık,Simon Storevik,Shannon Sherwin Moreino,Samuel A. Sprowls,Jianhua Han,Adam Lauko,Palavalasa Sravya,Gro V. Røsland,Katie M. Troike,Karl Johan Tronstad,Sabrina Wang,Katharina Sarnow,K. Kay,Taral R. Lunavat,Daniel J. Silver,Sahil Dayal,Justin V. Joseph,Erin E. Mulkearns-Hubert,Lars A. Rømo Ystaas,Gauravi M. Deshpande,Joris Guyon,Yadi Zhou,Capucine R. Magaut,Juliana Seder,Laura Neises,Sara E. Williford,Johannes Meiser,Andrew J. Scott,Peter Sajjakulnukit,Jason A. Mears,Rolf Bjerkvig,Abhishek A. Chakraborty,Thomas Daubon,Feixiong Cheng,Costas A. Lyssiotis,Daniel R. Wahl,Anita B. Hjelmeland,Jubayer A Hossain,Hrvoje Miletic,Justin D. Lathia +40 more
TL;DR: In this paper , the authors show that mitochondria transfer is a prevalent phenomenon in glioblastoma (GBM), the most frequent and malignant primary brain tumor, and identify horizontal mitochondria transfers from astrocytes as a mechanism that enhances tumorigenesis in GBM.
ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells
Ana Jimenez-Pascual,James S. Hale,James S. Hale,Anja Kordowski,Jamie Pugh,Daniel J. Silver,Daniel J. Silver,Defne Bayik,Defne Bayik,Gustavo Roversi,Tyler J. Alban,Tyler J. Alban,Tyler J. Alban,Shilpa Rao,Shilpa Rao,Rui Chen,Thomas M. McIntyre,Thomas M. McIntyre,Thomas M. McIntyre,Giorgio Colombo,Giulia Taraboletti,Karl O. Holmberg,Karin Forsberg-Nilsson,Justin D. Lathia,Justin D. Lathia,Justin D. Lathia,Florian A. Siebzehnrubl +26 more
TL;DR: A novel signaling loop that induces and maintains GSCs consisting of an atypical metalloproteinase, a disintegrin and metallOProteinase domain-like protein decysin 1 (ADAMDEC1), secreted by G SCs is identified.
Common astrocytic programs during brain development, injury and cancer
TL;DR: There are distinguishing roles for stem-cell-like astrocytes during brain development, in neurogenic niches in the adult, during attempted reactive neurogenesis after brain injury or disease and during brain tumorigenesis.
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