Daniel J. O’Connell
Brigham and Women's Hospital
6 Papers
25 Citations
Daniel J. O’Connell is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Wnt signaling pathway & Apical ectodermal ridge. The author has an hindex of 5, co-authored 6 publications.
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Papers
Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
Xiu-Ping Wang,Daniel J. O’Connell,Jennifer J. Lund,Irfan Saadi,Mari Kuraguchi,Annick Turbe-Doan,Resy Cavallesco,Hyun-Chul Kim,Peter J. Park,Hidemitsu Harada,Raju Kucherlapati,Raju Kucherlapati,Richard L. Maas +12 more
TL;DR: It is shown that supernumerary teeth can form from multiple regions of the jaw and that they are properly mineralized, vascularized, innervated and can start to form roots.
An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud
Dolrudee Jumlongras,Salil A. Lachke,Daniel J. O’Connell,Anton Aboukhalil,Anton Aboukhalil,Xiao Li,Sung E. Choe,Joshua W. K. Ho,Joshua W. K. Ho,Annick Turbe-Doan,Erin A. Robertson,Bjorn R. Olsen,Martha L. Bulyk,Martha L. Bulyk,Brad A. Amendt,Richard L. Maas +15 more
TL;DR: A direct molecular regulatory link between Pitx family members and Bmp4 gene expression in developing incisor epithelium is established and it is shown that this site supports Pitx binding and that the site is necessary to recapitulate aspects of endogenous BMP4 expression in developed craniofacial and limb tissues.
A Wnt-Bmp Feedback Circuit Controls Intertissue Signaling Dynamics in Tooth Organogenesis
Daniel J. O’Connell,Joshua W. K. Ho,Joshua W. K. Ho,Tadanori Mammoto,Annick Turbe-Doan,Joyce T. O’Connell,Psalm Haseley,Psalm Haseley,Samuel Koo,Samuel Koo,Nobuhiro Kamiya,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber,Peter J. Park,Peter J. Park,Peter J. Park,Richard L. Maas +17 more
TL;DR: A systems biology approach that combined the generation and analysis of large-scale spatiotemporal gene expression data with mouse genetic experiments to gain insight into the mechanisms that control epithelial-mesenchymal signaling interactions in the developing mouse molar tooth identified a critical signaling circuit that controls the coordinated genome-wide expression changes and reciprocal signaling molecule dynamics.
Network-based inference from complex proteomic mixtures using SNIPE
David P. Nusinow,Adam Kiezun,Daniel J. O’Connell,Joel M. Chick,Yingzi Yue,Richard L. Maas,Steven P. Gygi,Shamil R. Sunyaev +7 more
TL;DR: It is concluded that SNIPE can enhance the utility of shotgun proteomics data to facilitate the study of poorly detected proteins in complex mixtures.