Daniel Hornuss
University of Freiburg
21 Papers
78 Citations
Daniel Hornuss is an academic researcher from University of Freiburg. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 8 publications.
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Papers
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.
Sebastian Weigang,Jonas Fuchs,Gert Zimmer,Daniel Schnepf,Lisa Kern,Julius Beer,Hendrik Luxenburger,Jakob Ankerhold,Valeria Falcone,Janine Kemming,Maike Hofmann,Robert Thimme,Christoph Neumann-Haefelin,Svenja Ulferts,Robert Grosse,Daniel Hornuss,Yakup Tanriver,Siegbert Rieg,Dirk Wagner,Daniela Huzly,Martin Schwemmle,Marcus Panning,Georg Kochs +22 more
TL;DR: Weigang et al. as discussed by the authors used RT-qPCR and next-generation sequencing (NGS) of sequential respiratory specimens to identify several mutations in the SARS-CoV-2 genome late in infection.
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Identification of the Cellular Receptor of Clostridium spiroforme Toxin
Panagiotis Papatheodorou,Claudia Wilczek,Thilo Nölke,Gregor Guttenberg,Daniel Hornuss,Carsten Schwan,Klaus Aktories +6 more
TL;DR: This work reports on the recombinant production of the enzyme component and the binding component of C. spiroforme toxin in Bacillus megaterium and shows that CST enters target cells via the lipolysis-stimulated lipoprotein receptor (LSR), which has been recently identified as the host cell receptor of the binary toxins Clostridium difficile transferase and Clostridgeium perfringens iota toxin.
Clostridium difficile Binary Toxin CDT Induces Clustering of the Lipolysis-Stimulated Lipoprotein Receptor into Lipid Rafts
Panagiotis Papatheodorou,Daniel Hornuss,Thilo Nölke,Sarah Hemmasi,Jan Castonguay,Monica Picchianti,Monica Picchianti,Klaus Aktories +7 more
TL;DR: It is found by fluorescence microscopy that the binding component of CDT (CDTb) induces clustering of LSR into subcompartments of the plasma membrane, suggesting that oligomerization of the B component ofCDT is not the main trigger of this process.
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Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis
Bhagteshwar Singh,Suzannah Lant,Sofia Cividini,J. W. S. Cattrall,Lynsey Goodwin,Laura A Benjamin,Benedict D Michael,Ayaz Khawaja,Aline de Moura Brasil Matos,Walid Alkeridy,Andrea Pilotto,Durjoy Lahiri,Rebecca Rawlinson,S. Mhlanga,Evelyn C Lopez,Brendan F Sargent,Anushri Somasundaran,Arina Tamborska,Glynn W Webb,Komal Younas,Yaqub Al Sami,Heavenna Babu,Tristan Banks,Francesco Cavallieri,M. Cohen,Emma Davies,Shalley Dhar,Anna Fajardo Modol,Hamzah Z. Farooq,Jeffrey Harte,Samuel Hey,Albert Joseph,D. Karthikappallil,Daniel Kassahun,G. Lipunga,Rachel Mason,Thomas Hosker Minton,Gabrielle Mond,J. Poxon,Sophie Rabas,Germander Soothill,Marialuisa Zedde,Konstantin Yenkoyan,Bruce J. Brew,Erika W. Contini,Lucette A. Cysique,Xin Zhang,Pietro Maggi,Vincent Van Pesch,Jerome R. Lechien,Sven Saussez,Alex Heyse,Maria Lucia Brito Ferreira,Cristiane Nascimento Soares,Isabel Elicer,Laura Eugenín-von Bernhardi,Waleng Ñancupil Reyes,Rong Yin,Mohammed Azab,Foad Abd-Allah,A. Elkady,Simon Escalard,Jean-Christophe Corvol,Cécile Delorme,Pierre Tattevin,Kévin Bigaut,Norbert Lorenz,Daniel Hornuss,Jonas A. Hosp,Siegbert Rieg,Dirk Wagner,Benjamin Knier,Paul Lingor,Andrea Sylvia Winkler,A. Sharifi-Razavi,Shima T. Moein,SeyedAhmad SeyedAlinaghi,Saeidreza Jamalimoghadamsiahkali,Mauro Morassi,Alessandro Padovani,Marcello Giunta,Ilenia Libri,Simone Beretta,Sabrina Ravaglia,Matteo Foschi,Paolo Calabresi,Guido Primiano,Serenella Servidei,Nicola Biagio Mercuri,Claudio Liguori,Mariangela Pierantozzi,Loredana Sarmati,Federica Boso,Silvia Garazzino,Sara Mariotto,Kimani N Patrick,Oana Costache,Alexander Pincherle,Frederikus A. Klok,Roger M. Meza,Verónica Cabreira,Sofia R. Valdoleiros,Vanessa Oliveira,Igor Kaimovsky,Alla Guekht,Jasmin Jiemin Koh,E. Fernández Díaz,José María Barrios-López,Cristina Guijarro-Castro,Álvaro Beltrán-Corbellini,Javier Martínez‐Poles,A.M. Diezma-Martín,María Isabel Morales-Casado,S. García García,Gautier Breville,Matteo Coen,Marjolaine Uginet,Raphaël Bernard-Valnet,Renaud Du Pasquier,Yildiz Kaya,Loay H. Abdelnour,Claire M Rice,Hamish Morrison,Sylviane Defres,Saif Huda,Noelle Enright,Jane Hassell,Lucio D'Anna,Matthew Benger,László Sztriha,Eamon P. Raith,Krishna Chinthapalli,Ross Nortley,Ross Paterson,Arvind Chandratheva,David J. Werring,Samir Dervisevic,Kirsty Harkness,Ashwin Pinto,Dinesh V Jillella,Scott R. Beach,Kulothungan Gunasekaran,Ivan Rocha Ferreira da Silva,Krishna Nalleballe,Jon M Santoro,Tyler Scullen,Lora Kahn,Carla Kim,Kiran T. Thakur,Rajan B. Jain,Thirugnanam Umapathi,Timothy R Nicholson,James J. Sejvar,Eva Maria Hodel,Catrin Tudur Smith,Tom Solomon +155 more
TL;DR: The spectrum of neurological disease in hospitalised COVID-19 patients is described; clinical outcomes are characterised; factors associated with a poor outcome are investigated; and preliminary data suggest these may differ according to WHO regions and country income levels.
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Anosmia in COVID-19 patients
TL;DR: The majority of CO VID-19 patients have an objective anosmia and hyposmia, which often occurs unnoticed, and these symptoms may be related to the neuroinvasive propensity of SARS-COV-2 and the unusual presentation of COVID-19 disease manifestations.
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