Daniel Holoch
PSL Research University
5 Papers
2 Citations
Daniel Holoch is an academic researcher from PSL Research University. The author has contributed to research in topics: PRC2 & Chromatin. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Daniel Holoch include French Institute of Health and Medical Research & Curie Institute.
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Papers
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Eric Conway,Emilia Jerman,Evan Healy,Shinsuke Ito,Daniel Holoch,Giorgio Oliviero,Orla Deevy,Eleanor Glancy,Darren J. Fitzpatrick,Marlena Mucha,Ariane Watson,Alan M. Rice,Paul Chammas,Christine S. Huang,Indigo Pratt-Kelly,Yoko Koseki,Manabu Nakayama,Tomoyuki Ishikura,Gundula Streubel,Kieran Wynne,Karsten Hokamp,Aoife McLysaght,Claudio Ciferri,Luciano Di Croce,Gerard Cagney,Raphaël Margueron,Haruhiko Koseki,Adrian P. Bracken +27 more
TL;DR: PALI1/2 potentially link polycombs with transcriptional co-repressors in the regulation of cellular identity during development and in cancer.
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Chromatin biology: Breaking into the PRC2 cage
Daniel Holoch,Raphaël Margueron +1 more
TL;DR: New small-molecule inhibitors of the histone methyltransferase PRC2 interfere with the allosteric activation of enzymatic activity and provide important new tools for altering chromatin regulation.
3
A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
Arnaud de Muyt,Arnaud de Muyt,Alexandra Pyatnitskaya,Alexandra Pyatnitskaya,Jessica Andreani,Jessica Andreani,Lepakshi Ranjha,Claire Ramus,Raphaelle Laureau,Raphaelle Laureau,Ambra Fernandez-Vega,Ambra Fernandez-Vega,Daniel Holoch,Daniel Holoch,Elodie Girard,Jérôme Govin,Raphaël Margueron,Raphaël Margueron,Yohann Couté,Petr Cejka,Petr Cejka,Raphael Guerois,Raphael Guerois,Valérie Borde,Valérie Borde +24 more
TL;DR: The results suggest that the ZZS complex shepherds recombination intermediates toward crossovers as a dynamic structural module that connects recombination events to the chromosome axis.
The Polycomb protein Ezl1 mediates H3K9 and H3K27 methylation to repress transposable elements in Paramecium
Andrea Frapporti,Andrea Frapporti,Caridad Miró Pina,Olivier Arnaiz,Daniel Holoch,Takayuki Kawaguchi,Adeline Humbert,Evangelia Eleftheriou,Bérangère Lombard,Damarys Loew,Linda Sperling,Karine Guitot,Raphaël Margueron,Sandra Duharcourt +13 more
TL;DR: The authors show that the Enhancer-of-zeste-like protein Ezl1 from the unicellular eukaryote Paramecium tetraurelia, catalyzes methylation of histone H3 in vitro and in vivo with an apparent specificity toward K9 and K27, and controls the repression of transposable elements.
Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity
TL;DR: A rich and fast-evolving picture of the biochemical signals that govern PRC2 function is produced, with many exciting questions still remaining.