Daniel Handley
University of Pittsburgh
6 Papers
35 Citations
Daniel Handley is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Gene expression & Chromatin immunoprecipitation. The author has an hindex of 5, co-authored 5 publications.
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Papers
Inhibition and role of let-7d in idiopathic pulmonary fibrosis.
Kusum Pandit,David L. Corcoran,Hanadie Yousef,Manohar Yarlagadda,Argyris Tzouvelekis,Kevin F. Gibson,Kazuhisa Konishi,Samuel A. Yousem,Mandal K. Singh,Daniel Handley,Thomas J. Richards,Moisés Selman,Simon C. Watkins,Annie Pardo,Ahmi Ben-Yehudah,Demosthenes Bouros,Oliver Eickelberg,Prabir Ray,Panayiotis V. Benos,Naftali Kaminski +19 more
TL;DR: The down-regulation of let-7d in IPF and the profibrotic effects of this down- regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis.
Structural and regulatory characterization of the placental epigenome at its maternal interface.
TL;DR: It is concluded that the early gestational placental DNA methylome is highly organized and is significantly and globally associated with transcription.
Comprehensive analysis of the transcriptional response of human decidual cells to lipopolysaccharide stimulation.
Katherine P. Himes,Daniel Handley,Tianjiao Chu,Brian Burke,Kimberly Bunce,Hyagriv N. Simhan,David G. Peters +6 more
TL;DR: Novel, preliminary findings provide insight into possible mechanisms via which the host inflammatory response could contribute to preterm birth and warrant further investigation in preterm samples.
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Rare variants of the glucagon-like peptide-1 receptor (GLP1R) gene are overrepresented in a severe obesity cohort and associated with type 2 diabetes in the UK Biobank
Daniel Handley,S. Almansoori,Munemori Sato,Haitham Amin,Suzanne I. M. Alsters,Harvind C. Chahal,Sanjay Purkayastha,KG Murphy,Mieke M. van Haelst,Carel W. le Roux,Teck Shi Tan,Robin G. Walters,Fotios Drenos,Alexandra I. F. Blakemore +13 more
TL;DR: In this paper , rare, potentially deleterious mutations in the glucagon-like peptide 1 receptor gene (GLP1R) were associated with increased risk of type 2 diabetes.
Maternal gene expression profiling during pregnancy and preeclampsia in human peripheral blood mononuclear cells.
Augustine Rajakumar,Tianjiao Chu,Daniel Handley,Kimberly Bunce,Brian Burke,Carl A. Hubel,Arundhathi Jeyabalan,David G. Peters +7 more
TL;DR: A genome-wide transcriptome analysis identified an anti-proliferative and altered immune function cellular phenotype in severe preeclamptic samples of women with preeclampsia and provided a number of potential biomarkers for use in the further characterization of this disease.