Daniel H.S. Lee
Biogen Idec
2 Papers
95 Citations
Daniel H.S. Lee is an academic researcher from Biogen Idec. The author has contributed to research in topics: Intracellular & Internalization. The author has an hindex of 2, co-authored 2 publications.
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Papers
Consistent immunohistochemical detection of intracellular β-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex
TL;DR: Comparison of the effects of pretreatment immunohistochemical techniques for detecting intracellular beta-amyloid42 in pyramidal neurons of formalin-fixed Alzheimer's disease cortices suggests that the Abeta42 present in amyloid plaques may be structurally distinct from that located within the neurons perhaps due to differential binding proteins coupling or a consequence of formal in fixation.
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Targeting intracellular Aβ42 for Alzheimer's disease drug discovery
TL;DR: This work suggests that at least some of the amyloid plaques in the cerebrum and hippocampus may derive from the lysis of those neurons that are overburdened with intracellular Aβ42, and provides the scientific rationale for targeting the mechanisms that lead to the intraneuronal A β42 as a novel strategy for AD drug discovery.
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