Daniel Espinoza
University of Coimbra
22 Papers
298 Citations
Daniel Espinoza is an academic researcher from University of Coimbra. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 16, co-authored 21 publications. Previous affiliations of Daniel Espinoza include Joslin Diabetes Center & Beth Israel Deaconess Medical Center.
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Papers
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Yu-Hua Tseng,Efi Kokkotou,Tim J. Schulz,Tian Lian Huang,Jonathon N. Winnay,Cullen M. Taniguchi,Thien T. Tran,Ryo Suzuki,Daniel Espinoza,Yuji Yamamoto,Molly J. Ahrens,Andrew T. Dudley,Andrew W. Norris,Rohit N. Kulkarni,C. Ronald Kahn +14 more
TL;DR: It is demonstrated that whereas some members of the family of bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail.
Erratum: New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure (Nature (2008) 454 (1000-1004))
Yu-Hua Tseng,Efi Kokkotou,Tim J. Schulz,Tian Lian Huang,Jonathon N. Winnay,Cullen M. Taniguchi,Thien T. Tran,Ryo Suzuki,Daniel Espinoza,Yuji Yamamoto,Molly J. Ahrens,Andrew T. Dudley,Andrew W. Norris,Rohit N. Kulkarni,C. Ronald Kahn +14 more
TL;DR: This corrects the article to show that the H2O2/H2O/O2 mixture is dominated by the H3O/ O2 mixture, rather than the O2/O3 mixture, which is more commonly associated with H2Os.
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
Kristy L. Townsend,Ryo Suzuki,Tian Lian Huang,Enxuan Jing,Tim J. Schulz,Kevin Y. Lee,Cullen M. Taniguchi,Daniel Espinoza,Lindsay E. McDougall,Hongbin Zhang,Tong-Chuan He,Efi Kokkotou,Yu-Hua Tseng +12 more
TL;DR: Systemic treatment of diet‐induced obese mice with BMP7 resulted in increased energy expenditure and decreased food intake, leading to a significant reduction in body weight and improvement of metabolic syndrome, and suggests new therapeutic approaches for obesity and its comorbidities.
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Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
Hongbin Zhang,Tim J. Schulz,Daniel Espinoza,Tian Lian Huang,Brice Emanuelli,Karsten Kristiansen,Yu-Hua Tseng +6 more
TL;DR: Using a series of sequential deletion mutants of the pref-1 promoter linked to the luciferase gene and chromatin immunoprecipitation, it is demonstrated that the promoter-proximal SBE was critical in mediating BMP7's suppressive effect on Pref-1 transcription.
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Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-Associated Pathways
Aaron M. Cypess,Hongbin Zhang,Hongbin Zhang,Tim J. Schulz,Tian Lian Huang,Daniel Espinoza,Karsten Kristiansen,Terry G. Unterman,Yu-Hua Tseng +8 more
TL;DR: It is proposed that insulin/IGF-I act through IRS-1 phosphorylation to stimulate differentiation of brown preadipocytes via two complementary pathways: 1) the Ras-ERK1/2 pathway to activate CREB and 2) the phosphoinositide 3 kinase-Akt pathway to deactivate FoxO1.