Daniel E. Leisman
Harvard University
37 Papers
95 Citations
Daniel E. Leisman is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Sepsis. The author has an hindex of 13, co-authored 30 publications. Previous affiliations of Daniel E. Leisman include Hofstra University & The Feinstein Institute for Medical Research.
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Papers
Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
Daniel E. Leisman,Daniel E. Leisman,Daniel E. Leisman,Lukas Ronner,Lukas Ronner,Rachel Pinotti,Matthew D. Taylor,Matthew D. Taylor,Pratik Sinha,Carolyn S. Calfee,Alexandre V. Hirayama,Fiore Mastroiani,Cameron J. Turtle,Michael O. Harhay,Matthieu Legrand,Clifford S. Deutschman,Clifford S. Deutschman +16 more
TL;DR: The findings question the role of a cytokine storm in COVID-19-induced organ dysfunction and the potential role of anti-cytokine and immune-modulating treatments in patients with the disease.
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Association of Fluid Resuscitation Initiation Within 30 Minutes of Severe Sepsis and Septic Shock Recognition With Reduced Mortality and Length of Stay
Daniel E. Leisman,Benjamin Wie,Martin E. Doerfler,Andrea R. Bianculli,Mary Frances Ward,Meredith Akerman,John D’Angelo,Jason D'Amore +7 more
TL;DR: The time of intravenous fluid resuscitation initiation was associated with improved mortality and could be used as an easier obtained alternative to intravenous fluids completion time as a performance indicator in severe sepsis and septic shock management.
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Patterns and Outcomes Associated With Timeliness of Initial Crystalloid Resuscitation in a Prospective Sepsis and Septic Shock Cohort.
Daniel E. Leisman,Chananya Goldman,Martin E. Doerfler,Kevin D. Masick,Susan Dries,Eric Hamilton,Mangala Narasimhan,Gulrukh Zaidi,Jason D'Amore,John D’Angelo +9 more
TL;DR: Crystalloid was initiated significantly later with comorbid heart failure and renal failure, with absence of fever or hypotension, and in inpatient-presenting sepsis, while earlier crystalloid initiation was associated with decreased mortality.
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Predictors, Prevalence, and Outcomes of Early Crystalloid Responsiveness Among Initially Hypotensive Patients With Sepsis and Septic Shock.
Daniel E. Leisman,Martin E. Doerfler,Sandra M. Schneider,Sandra M. Schneider,Kevin D. Masick,Jason D'Amore,John D’Angelo +6 more
TL;DR: Two in three hypotensive sepsis patients were responsive to initial fluid resuscitation and refractoriness, and heart failure, hypothermia, immunocompromise, hyperlactemia, and coagulopathy were associated with the refractory phenotype.
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