Daniel E. Harper
University of Michigan
29 Papers
87 Citations
Daniel E. Harper is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Chronic pain. The author has an hindex of 13, co-authored 24 publications. Previous affiliations of Daniel E. Harper include Emory University & University of North Carolina at Chapel Hill.
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Papers
Pain Mechanisms and Centralized Pain in Temporomandibular Disorders
TL;DR: This article uses other centralized chronic pain conditions as a guide, and it suggests that the mechanistic variability in TMD pain etiology has prevented us from adequately treating many individuals who are diagnosed with the condition.
149
Endogenous opioidergic dysregulation of pain in fibromyalgia: a PET and fMRI study.
Andrew Schrepf,Daniel E. Harper,Steven E. Harte,Heng Wang,Eric Ichesco,Johnson P. Hampson,Jon Kar Zubieta,Daniel J. Clauw,Richard E. Harris +8 more
TL;DR: It is suggested that dysregulation of the endogenous opioid system in FM could lead to less excitation in antinociceptive brain regions by incoming noxious stimulation, resulting in the hyperalgesia and allodynia commonly observed in this population.
Resting Functional Connectivity of the Periaqueductal Gray Is Associated With Normal Inhibition and Pathological Facilitation in Conditioned Pain Modulation.
Daniel E. Harper,Eric Ichesco,Andrew Schrepf,Johnson P. Hampson,Daniel J. Clauw,Tobias Schmidt-Wilcke,Richard E. Harris,Steven E. Harte +7 more
TL;DR: Findings indicate that variation in the strength of the PAG resting functional connectivity can explain some of the normal variability in CPM, and that pain-facilitative CPM observed in FM patients likely involves attenuation of pain inhibitory as well as amplification of pain facilitative processes in the central nervous system.
94
Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: a MAPP Research Network study.
Andrew Schrepf,David A. Williams,Robert Gallop,Robert Gallop,Bruce D. Naliboff,Neil Basu,Chelsea M. Kaplan,Daniel E. Harper,J. Richard Landis,J. Quentin Clemens,Eric Strachan,James W. Griffith,Niloofar Afari,Niloofar Afari,Afton L. Hassett,Michel A. Pontari,Daniel J. Clauw,Steven E. Harte +17 more
TL;DR: In secondary analyses, it is found that Generalized Sensory Sensitivity particularly is associated with the presence of comorbid COPCs, whereas SPACE shows modest associations with measures of disability and urinary symptoms.
77
Changes in Pain from a Repetitive Thermal Stimulus: The Roles of Adaptation and Sensitization
TL;DR: The finding in the present study that vibratory gating of pain is significantly (inversely) related to the rate of sensitization suggests that the latter also reflects segmental processes, indicating that adaptation and sensitization occur at early stages of sensory information processing.