Daniel DeWoskin
University of Michigan
9 Papers
8 Citations
Daniel DeWoskin is an academic researcher from University of Michigan. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Daniel DeWoskin include San Francisco State University & Lawrence Berkeley National Laboratory.
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Papers
GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time
Jihwan Myung,Jihwan Myung,Sungho Hong,Daniel DeWoskin,Erik De Schutter,Daniel B. Forger,Toru Takumi,Toru Takumi +7 more
TL;DR: It is shown that increasing day-length changes the pattern of chloride transporter expression, yielding more excitatory GABA synaptic input, and that blocking GABAA signaling or the chloride transporter disrupts the unique phase and period organization induced by the day length.
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Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.
TL;DR: This work proposes the existence of two types of differentially regulated GABA signaling—fast signaling that regulates neuronal output, and slow signaling that modulates synchrony between neurons—a hypothesis that can explain many previous experimental results and provides an important tool for circadian research.
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It is not the parts, but how they interact that determines the behaviour of circadian rhythms across scales and organisms
TL;DR: It is found that refitting the most detailed model of the mammalian circadian clock, so that the coupling between cells matches experimental data, yields different dynamics and makes an interesting prediction that also matches experimentalData: individual cells are bistable, and network coupling removes this bistability and causes the network to be more robust to external perturbations.
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Dynamic models of metastatic tumor growth
Daniel DeWoskin,M. Higley,Kyle Lemoi,B. Owens,A. Rahman,H. Rotstein,D. Rumschitzki,Sumanth Swaminathan,M. Tanzy,O. Varfolomiyev,T. Witelski,V. Zubkov +11 more
- 01 Jan 2011
TL;DR: This work considers the use of mathematical models to describe the progression of cancer and how the influence of anti-cancer drugs can be incorporated into these models.
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•Dissertation
Multiscale Modeling of Coupled Oscillators with Applications to the Mammalian Circadian Clock.
Daniel DeWoskin
- 01 Jan 2015
TL;DR: Multiscale Modeling of Coupled Oscillators with Applications to the Mammalian Circadian Clock and their applications to the mammaliancircadian clock are studied.
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