Daniel D. Shaye
Columbia University
10 Papers
22 Citations
Daniel D. Shaye is an academic researcher from Columbia University. The author has contributed to research in topics: Caenorhabditis elegans & Biology. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Daniel D. Shaye include University of Illinois at Chicago & Howard Hughes Medical Institute.
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Papers
OrthoList: a compendium of C. elegans genes with human orthologs.
Daniel D. Shaye,Iva Greenwald +1 more
TL;DR: It is anticipated that OrthoList will be of considerable utility to C. elegans researchers for streamlining RNAi screens, by focusing on genes with apparent human orthologs, thus reducing screening effort by ∼60%.
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Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans.
Daniel D. Shaye,Iva Greenwald +1 more
TL;DR: A novel mode of crosstalk between the epidermal growth factor receptor/Ras/mitogen-activated protein kinase cascade and the LIN-12/Notch pathway during Caenorhabditis elegans vulval development is defined and a ‘downregulation targeting signal’ (DTS) in theLIN-12 intracellular domain is identified, which encompasses a di-leucine-containing endocytic sorting motif.
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LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans
TL;DR: Evidence is provided that the lateral signal-inhibiting activity of LIN-12 resides in the extracellular domain and occurs at the apical surface of the VPCs, and two trans-acting factors that are required for post-internalization trafficking and degradation are identified.
The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons.
Daniel D. Shaye,Iva Greenwald +1 more
TL;DR: Using genetic analysis and live imaging, it is shown that exc-6 regulates MT and F-actin accumulation at EC tips and dynamics of basolateral-localized MTs, indicating that EXC-6 organizes F- actin and MT cytoskeletons during tubulogenesis.
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A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo
TL;DR: An EXC-5/FGD-CDC-42 pathway regulates the two formins INFT-2/INF2 and CYK-1/mDia to control F-actin levels and modulate cell outgrowth during tubulogenesis in C. elegans.
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