Daniel Condliffe
Queen Mary University of London
5 Papers
Daniel Condliffe is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Daniel Condliffe include King's College London.
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Papers
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Katie Lunnon,Rebecca G. Smith,Eilis Hannon,Philip L. De Jager,Gyan Srivastava,Manuela Volta,Claire Troakes,Safa Al-Sarraj,Joe Burrage,Ruby Macdonald,Daniel Condliffe,Lorna W. Harries,Pavel Katsel,Vahram Haroutunian,Zachary Kaminsky,C Joachim,John Powell,Simon Lovestone,David A. Bennett,Leonard C. Schalkwyk,Jonathan Mill +20 more
TL;DR: This study represents, to the best of the knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.
Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology
Rebecca G. Smith,Eilis Hannon,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Lori B. Chibnik,Lori B. Chibnik,Simon J. Lott,Daniel Condliffe,Adam Smith,Vahram Haroutunian,Vahram Haroutunian,Claire Troakes,Safa Al-Sarraj,David A. Bennett,John Powell,Simon Lovestone,Leonard C. Schalkwyk,Jonathan Mill,Katie Lunnon +19 more
TL;DR: Alzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain, and the role of epigenetic regulation in this dysregulation is still unclear.
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Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
Daniel Condliffe,Andrew Wong,Claire Troakes,Petroula Proitsi,Yogen Patel,Leonidas Chouliaras,Cathy Fernandes,Jonathan D. Cooper,Simon Lovestone,Leonard C. Schalkwyk,Jonathan Mill,Jonathan Mill,Katie Lunnon +12 more
TL;DR: A significant AD-associated decrease in global 5-hydroxymethylcytosine in entorhinal cortex and cerebellum, and differences in 5-formylcytOSine levels between brain regions are identified, which implicates a role for epigenetic alterations in AD.
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Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain
Adam Smith,Rebecca G. Smith,Daniel Condliffe,Eilis Hannon,Leonard C. Schalkwyk,Jonathan Mill,Katie Lunnon +6 more
TL;DR: It is highlighted that extending genetic studies of TREM2 in AD to investigate epigenetic changes may nominate additional mechanisms by which disruption to this gene increases risk.
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Acute social isolation alters neurogenomic state in songbird forebrain.
Jimin George,Zachary W. Bell,Daniel Condliffe,Kirstin Dohrer,Teresa Abaurrea,Karen A. Spencer,Albertine Leitão,Manfred Gahr,Paul J. Hurd,David F. Clayton +9 more
TL;DR: Social isolation has rapid consequences on gene activity in a higher integrative center of the brain, triggering epigenetic mechanisms that may influence processing of ongoing experience.
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