Daniel Chu
University of California, San Francisco
6 Papers
1 Citations
Daniel Chu is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Transgene & Electroporation. The author has an hindex of 2, co-authored 6 publications.
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Papers
Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme
Alex J. Hughes,Hikaru Miyazaki,Maxwell C. Coyle,Jesse Q. Zhang,Matthew T. Laurie,Daniel Chu,Zuzana Vavrusova,Richard A. Schneider,Ophir D. Klein,Zev J. Gartner +9 more
TL;DR: The robustness and versatility of this strategy for sculpting tissue interfaces is demonstrated by directing the morphogenesis of a variety of folded tissue forms from patterns of mesenchymal condensates.
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Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development.
TL;DR: A novel, sensitive, tunable, and stable inducible-promoter system for high-resolution gene manipulation in vivo to control the timing, spatial domains, and levels of gene misexpression throughout avian development.
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Stable integration of an optimized inducible promoter system enables spatiotemporal control of gene expression throughout avian development
TL;DR: A novel, sensitive, tunable, and stable inducible-promoter system for high-resolution gene manipulation in vivo that produces robust transgene expression in the presence of doxycycline at any point during embryonic development in ovo or in culture.
Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution
TL;DR: In this article, the authors uncover mechanisms establishing species-specific levels of Matrix metalloproteinase 13 and bone resorption in quail and duck, and show that quail show greater activation of, and sensitivity to Transforming Growth Factor-Beta (TGF{beta}) signaling than duck.
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Tissue Folding by Mechanical Compaction of the Mesenchyme
Alex J. Hughes,Hikaru Miyazaki,Maxwell C. Coyle,Jesse Q. Zhang,Matthew T. Laurie,Daniel Chu,Zuzana Vavrusova,Richard A. Schneider,Ophir D. Klein,Zev J. Gartner +9 more
TL;DR: These studies provide insight into the active mechanical properties of the embryonic mesenchyme and establish entirely new strategies for more robustly directing tissue morphogenesis ex vivo, without genetic engineering.
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