Daniel Bottomley
University of Leeds
7 Papers
7 Citations
Daniel Bottomley is an academic researcher from University of Leeds. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 3, co-authored 7 publications. Previous affiliations of Daniel Bottomley include St James's University Hospital.
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Papers
KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study (vol 108, pg 1495, 2013)
N.C.T. van Grieken,Toru Aoyama,Philip A. Chambers,Daniel Bottomley,Lindsay C. Ward,I. Inam,Tineke E. Buffart,Kakoli Das,T. Lim,Brendan Pang,Shen Li Zhang,Iain Beehuat Tan,Beatriz Carvalho,D.A.M. Heideman,Yohei Miyagi,Yoichi Kameda,Tomio Arai,Gerrit A. Meijer,Akira Tsuburaya,Puay Hoon Tan,Takaki Yoshikawa +20 more
TL;DR: The authors noted the misspelling of the name of the second author, T Aoyama, and the correct spelling is now displayed above.
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Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq): A versatile and ultra-sensitive UMI-based NGS library preparation technology, for use with cfDNA and cfRNA.
Thomas L. Dunwell,Simon C. Dailey,Jihang Yu,Philipp W. Becker,Sarah Scaife,Susan D. Richman,Henry M. Wood,Hayley L. Slaney,Daniel Bottomley,Xiangsheng Yang,Hui Xiao,Anine Larsen Ottestad,Sissel Gyrid Freim Wahl,Bjørn Henning Grønberg,Hong Yan Dai,Guoliang Fu +15 more
TL;DR: ATOM-Seq’s strengths and versatility avoid the major limitations of both PCR- and ligation-based approaches, and its suitability for clinical testing is illustrated by showing high concordance rates between paired cfDNA and FFPE clinical samples.
Microbiome Analysis of More Than 2,000 NHS Bowel Cancer Screening Programme Samples Shows the Potential to Improve Screening Accuracy
Caroline Young,Henry M. Wood,Alba Fuentes Balaguer,Daniel Bottomley,Niall Gallop,Lyndsay Wilkinson,Sally C Benton,Martin Brealey,Cerin John,Carole Burtonwood,Kelsey N. Thompson,Yan Yan,Jennifer H. Barrett,Eva Morris,Eva Morris,Curtis Huttenhower,Philip Quirke +16 more
TL;DR: Microbiome features can be assessed using gFOBT samples collected and processed routinely by a national colorectal cancer screening program to improve accuracy as a first- or second-tier screen, raising the potential of an inexpensive qPCR test.
Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations
Simon Gollins,Nicholas P. West,David Sebag-Montefiore,Arthur Sun Myint,Mark P Saunders,Shabbir Susnerwala,Phil Quirke,Sharadah Essapen,Leslie Samuel,Bruce Sizer,Jane Worlding,K Southward,Gemma Hemmings,E Tinkler-Hundal,M Taylor,Daniel Bottomley,Philip A. Chambers,Emma Lawrie,Andre Lopes,Sandy Beare +19 more
TL;DR: For the first time using pre-operative rectal CRT, emergence of clinically important new resection mutations is described, likely reflecting intratumoural heterogeneity manifesting either as treatment-driven selective clonal expansion or a geographical biopsy sampling miss.
Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer.
Anna Wilkins,Elisa Fontana,Elisa Fontana,Gift Nyamundanda,Chanthirika Ragulan,Yatish Patil,David Mansfield,Jennifer Kingston,Fiona Errington-Mais,Daniel Bottomley,Katharina von Loga,Katharina von Loga,Hannah Bye,Hannah Bye,Paul Carter,Paul Carter,E Tinkler-Hundal,A Noshirwani,Jessica A. Downs,Magnus T. Dillon,Sandra Demaria,David Sebag-Montefiore,Kevin J. Harrington,Nicholas P. West,Alan Melcher,Anguraj Sadanandam +25 more
TL;DR: In this paper, a change in tumor cell density (ΔTCD) was used to assess rectal tumor response to neoadjuvant radiotherapy/chemoradiation (RT/CRT) and ΔTCD was subjected to k-means clustering to classify patients into different response categories.