Daniel Beisang
University of Minnesota
18 Papers
6 Citations
Daniel Beisang is an academic researcher from University of Minnesota. The author has contributed to research in topics: Untranslated region & Messenger RNA. The author has an hindex of 9, co-authored 18 publications.
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Papers
T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.
Ryan W. Nelson,Daniel Beisang,Noah J. Tubo,Thamotharampillai Dileepan,Darin L. Wiesner,Kirsten Nielsen,Marcel Wüthrich,Bruce S. Klein,Dmitri I. Kotov,Justin A. Spanier,Brian T. Fife,James J. Moon,Marc K. Jenkins +12 more
TL;DR: It is found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to cross-react on the same TCR, which can reduce the size of certain foreign peptide-specific T cell populations and might allow Tcell populations specific for tissue-restricted self peptides to cause autoimmunity after infection.
167
Analysis of CUGBP1 Targets Identifies GU-Repeat Sequences That Mediate Rapid mRNA Decay
Bernd Rattenbacher,Daniel Beisang,Darin L. Wiesner,Jonathan C. Jeschke,Maximilian von Hohenberg,Irina A. St. Louis-Vlasova,Paul R. Bohjanen +6 more
TL;DR: The results suggest that CUGBP1 coordinately regulates the mRNA decay of a network of transcripts involved in cell growth, cell motility, and apoptosis.
129
Lumacaftor/ivacaftor therapy fails to increase insulin secretion in F508del/F508del CF patients.
Amir Moheet,Daniel Beisang,Lin Zhang,Scott D. Sagel,Jill M. VanDalfsen,Sonya L. Heltshe,Carla A. Frederick,Michelle Mann,Nicholas Antos,Joanne Billings,Steven M. Rowe,Antoinette Moran +11 more
TL;DR: Lumacaftor/ivacaftors therapy did not improve insulin secretion or glucose tolerance in patients with CF who were homozygous for the F508del mutation.
49
Global assessment of GU-rich regulatory content and function in the human transcriptome
Anason S. Halees,Edward Hitti,Maher Al-Saif,Linah Mahmoud,Irina Vlasova-St. Louis,Daniel Beisang,Paul R. Bohjanen,Khalid S.A. Khabar +7 more
TL;DR: It is found that at least 5% of human genes contain GREs in their 3’UTRs with functional over-representation in genes involved in transcription, nucleic acid metabolism, developmental processes, and neurogenesis.
47
Mesenchymal stem cells in the pathogenesis and treatment of bronchopulmonary dysplasia: a clinical review
TL;DR: Conurrent high-quality basic science, translational, and clinical studies investigating the fundamental pathophysiology underlying BPD, therapeutic mechanisms of exogenous MSCs, and logistics of translating cellular therapies will be important areas of future research.