Daniel Barth
RWTH Aachen University
8 Papers
11 Citations
Daniel Barth is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Epithelial sodium channel & Mechanosensitive channels. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Daniel Barth include University of Otago.
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Papers
Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands
Daniel Barth,Martin Fronius +1 more
TL;DR: Results suggest that ASICs do have an intrinsic ability to respond to mechanical force, supporting their role as mechanosensors in certain local environments.
Species-Specific Regulation of TRPM2 by PI(4,5)P 2 via the Membrane Interfacial Cavity.
TL;DR: In this paper, the functional effect of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), commonly referred to as PIP2, on different TRPM2 orthologues was analyzed.
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Mechanical activation of epithelial Na+ channel relies on an interdependent activity of the extracellular matrix and extracellular N-glycans of αENaC
Fenja Knoepp,Zoe Ashley,Daniel Barth,Marina Kazantseva,Pawel P. Szczesniak,Wolfgang Clauss,Mike Althaus,Diego Alvarez de la Rosa,Martin Fronius +8 more
TL;DR: An interdependent activity of ENaC and the ECM that mediates SF effects in murine arteries and heterologously expressed channels is reported and the role of channel N-glycans is highlighted for the translation of mechanical force into cellular signals.
N‐Glycan and Heparan Sulphate Components of the Extracellular Matrix are Essential for Laminar Shear Stress Response of the Epithelial Sodium Channel (ENaC)
TL;DR: The epithelial sodium channel (ENaC), a mechanosensitive ion channel, is known to be activated by laminar shear stress (LSS) and it is hypothesised that the large extracellular loops of ENaC interact with each other.
Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC.
Fenja Knoepp,Zoe Ashley,Daniel Barth,Jan-Peter Baldin,Michael Jennings,Marina Kazantseva,Eng Leng Saw,Rajesh Katare,Diego Alvarez de la Rosa,Norbert Weissmann,Martin Fronius +10 more
TL;DR: Glycosylated asparagines in the palm and knuckle domains of αENaC are important for SF sensing in accordance with the force-from-filament principle, and may provide a connection to the ECM that facilitates vascular responsiveness contributing to blood pressure regulation.