Daniel B. Deegan
Wake Forest Institute for Regenerative Medicine
7 Papers
3 Citations
Daniel B. Deegan is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Decellularization & Chemistry. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Daniel B. Deegan include Wake Forest University & Virginia Tech.
Chat about Author
Papers
Bioengineered transplantable porcine livers with re-endothelialized vasculature
In Kap Ko,Li Peng,Andrea Peloso,Charesa Smith,Abritee Dhal,Daniel B. Deegan,Cindy Zimmerman,Cara Clouse,Weixin Zhao,Thomas Shupe,Shay Soker,James J. Yoo,Anthony Atala +12 more
TL;DR: It is demonstrated, for the first time, that vascularized bioengineered livers, of clinically relevant size, can be transplanted and maintained in vivo, and represents the first step towards generating engineered livers for transplantation to patients with end-stage liver failure.
141
CARD29: An Acellular Biologic Extracellular Matrix (ECM) Envelope for Cardiovascular Implantable Electronic Devices: Preclinical Evaluation
TL;DR: In this paper , the authors used a preclinical model to investigate the effect of ECM envelopes on the implant of pacemakers in a single-chamber pacemaker (PM) implant.
3
Translational Regenerative Medicine—Hepatic Systems
Abritee Dhal,Dipen Vyas,Emma C. Moran,Daniel B. Deegan,Shay Soker,Pedro M. Baptista +5 more
- 01 Jan 2015
TL;DR: Some of the most common liver diseases and numerous novel regenerative therapies in development or already translated into the clinic, that rely on liver regeneration are described.
1
Stiffness of hyaluronic acid gels containing liver extracellular matrix supports human hepatocyte function and alters cell morphology
Daniel B. Deegan,Daniel B. Deegan,Cynthia Zimmerman,Aleksander Skardal,Anthony Atala,Thomas Shupe +5 more
TL;DR: Gel stiffness affected primary human hepatocyte cell adhesion, functional marker expression, and morphological characteristics dependent on both the presence of liver ECM in gel substrates and time in culture.
Reduced fibrous capsule elastic fibers from biologic ECM-enveloped CIEDs in minipigs, supported with a novel compression mechanics model
Roche C. de Guzman,Allison Meer,Aidan Mathews,Atara Israel,Michael Moses,Clarence Sams,Daniel B. Deegan +6 more
TL;DR: The biologic envelope composed of decellularized porcine small intestine submucosa ECM for CIEDs promoted fibrous tissues with less elastic fibers, and novel compression modeling analyses directly correlated this singular reduction to more desirable subcutaneous tissue mechanics.