Daniel Auge
University of Erlangen-Nuremberg
10 Papers
33 Citations
Daniel Auge is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Organic anion-transporting polypeptide & Aceclofenac. The author has an hindex of 9, co-authored 10 publications.
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Papers
The Influence of Macrolide Antibiotics on the Uptake of Organic Anions and Drugs Mediated by OATP1B1 and OATP1B3
Annick Seithel,Sonja Eberl,Katrin Singer,Daniel Auge,Georg Heinkele,Nadine B. Wolf,Frank Dörje,Martin F. Fromm,Jörg König +8 more
TL;DR: Results indicate that alterations of uptake transporter function by certain macrolides/ketolides have to be considered as a potential additional mechanism underlying drug-drug interactions.
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Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high‐performance liquid chromatography
TL;DR: A liquid-liquid extraction-based reversed-phase HPLC method with UV detection was validated and applied for the analysis of aceclofenac and three of its metabolites and its metabolites following administration of a single 100 mg oral dose to three healthy male volunteers.
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N 1 -methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin–trimethoprim interaction
Fabian Müller,Constanza Pontones,Bertold Renner,Maren Mieth,Eva Hoier,Daniel Auge,Renke Maas,Oliver Zolk,Martin F. Fromm +8 more
TL;DR: These data on the metformin–trimethoprim interaction support the potential utility of N1-methylnicotinamide as an endogenous probe for renal drug–drug interactions with involvement of renal cation transporters.
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Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1)
TL;DR: High (but still physiological) concentrations of l-arginine can inhibit CAT1-mediated cellular uptake of ADMA, and in its physiological concentration range ADMA is unlikely to impair CAT2-mediated transport of l -arginines.
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The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost.
Michaela E. Kraft,Hartmut Glaeser,Kathrin Mandery,Jörg König,Daniel Auge,Martin F. Fromm,Ursula Schlötzer-Schrehardt,Ulrich Welge-Lussen,Friedrich E. Kruse,Oliver Zolk +9 more
TL;DR: The results presented herein suggest that at least OATP2A1 plays a role in the intraocular disposition of the therapeutically used prostanoid latanoprost.
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