Daniel Andergassen
Harvard University
7 Papers
21 Citations
Daniel Andergassen is an academic researcher from Harvard University. The author has contributed to research in topics: X-inactivation & Gene. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Daniel Andergassen include Technische Universität München.
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Papers
Cis and trans effects differentially contribute to the evolution of promoters and enhancers
Kaia Mattioli,Winona Oliveros,Chiara Gerhardinger,Daniel Andergassen,Philipp G. Maass,John L. Rinn,Marta Melé +6 more
TL;DR: This work uses massively parallel reporter assays to directly measure the transcriptional outputs of thousands of individual regulatory elements in embryonic stem cells and finds that cis effects are widespread across transcribed regulatory elements, and the strongest trans effects are associated with the disruption of motifs recognized by strong transcriptional activators.
In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation.
Daniel Andergassen,Zachary D. Smith,Jordan P. Lewandowski,Chiara Gerhardinger,Alexander Meissner,Alexander Meissner,John L. Rinn +6 more
TL;DR: The largest transcriptional effect was observed in all strains lacking the Firre locus, indicating that this locus is the main driver for these autosomal expression signatures.
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In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation
Daniel Andergassen,Zachary D. Smith,Jordan P. Lewandowski,Chiara Gerhardinger,Alexander Meissner,Alexander Meissner,John L. Rinn +6 more
TL;DR: The largest transcriptional effect was observed in all strains lacking the Firre locus, indicating that this locus is the main driver for these autosomal expression signatures.
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Analysis of regulatory element evolution between human and mouse reveals a lack ofcis-transcompensation
Kaia Mattioli,Winona Oliveros,Chiara Gerhardinger,Daniel Andergassen,Philipp G. Maass,John L. Rinn,Marta Melé +6 more
TL;DR: The use of massively parallel reporter assays to directly measure cis and trans effects between human and mouse embryonic stem cells at thousands of individual regulatory elements indicates that studying the evolution of individual Regulatory elements is pivotal to understand the tempo and mode of gene expression evolution.
Diverse mechanisms for epigenetic imprinting in mammals
Daniel Andergassen,Daniel Andergassen,Zachary D. Smith,Zachary D. Smith,Zachary D. Smith,John L. Rinn,Alexander Meissner +6 more
TL;DR: In this paper, the authors systematically disrupted multiple essential epigenetic pathways within polymorphic F1 zygotes to examine postimplantation effects on canonical and non-canonical genomic imprinting as well as X chromosome inactivation.