Danie Daaboul
4 Papers
Danie Daaboul is an academic researcher. The author has contributed to research in topics: Phosphorylation & Translation (biology). The author has co-authored 2 publications.
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Papers
Direct control of translational elongation by TAOK2β highlights altered protein synthesis as a fundamental underlying component of autism
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,Matthias Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K. Singh,Kent E. Duncan,Froylan Calderon de Anda +18 more
TL;DR: This work aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the response of the immune system to EMTs.
TAOK2β represses translation via phosphorylation of eEF2 and ameliorates exaggerated protein synthesis in a mouse model of 16p11.2 microdeletion-driven autism
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,Matthias Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K. Singh,Kent E. Duncan,Froylan Calderon de Anda +18 more
TL;DR: The results uncover a critical role of TAOK2β as a regulator of protein synthesis and support the idea that translational control is a common endpoint of ASD-associated signaling pathways.
The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation
Melad E.G. Henis,Tabitha Rücker,Robin Scharrenberg,Melanie Richter,Lucas L. Baltussen,Shuai Hong,Durga Praveen Meka,Birgit Schwanke,Nagammal Neelagandan,Danie Daaboul,Nadeem Murtaza,Christoph Krisp,Sönke Harder,Hartmut Schlüter,M. Kneussel,Irm Hermans-Borgmeyer,Joris de Wit,Karun K Singh,Kent E Duncan,Froylan Calderon de Anda +19 more
TL;DR: It is shown that TAOK2 can directly phosphorylate eEF2 on the same regulatory site, but functions independently of eEF2K signaling, which suggests an eEF2K-independent signaling pathway for control of translation elongation.
A dynamic gene regulatory code drives synaptic development of hippocampal granule cells
Blanca Lorente-Echeverría,Danie Daaboul,Jeroen Vandensteen,Gabriele Marcassa,Willem Naert,Joris Vandenbempt,Elke Leysen,Malou Reverendo,Ine Vlaeminck,Lise Vervloessem,Jochen Lamote,Suresh Poovathingal,Kristofer Davie,Keimpe D. Wierda,Dan Dascenco,Stein Aerts,Joris de Wit +16 more
TL;DR: Researchers reconstructed gene regulatory networks in hippocampal granule cells, revealing a dynamic code that drives synaptic development through sequential regulations, identifying key transcription factors and target genes involved in cell morphogenesis, synapse organization, and plasticity.