Dang Wen
21 Papers
16 Citations
Dang Wen is an academic researcher. The author has contributed to research in topics: Virus & Recombinant virus. The author has an hindex of 4, co-authored 21 publications.
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Papers
Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway
Wei Zhang,Fan Yang,Zixiang Zhu,Yang Yang,Zhifang Wang,Weijun Cao,Dang Wen,Li Linlin,Ruoqing Mao,Yongjie Liu,Tian Hong,Keshan Zhang,Xiangtao Liu,Junwu Ma,Haixue Zheng +14 more
TL;DR: A novel role for DNAJA3 in the host’s antiviral response is described by inducing the lysosomal degradation of VP1 and attenuating the VP1-induced suppressive effect on the IFN-β signaling pathway.
44
The Nucleoprotein and Phosphoprotein of Peste des Petits Ruminants Virus Inhibit Interferons Signaling by Blocking the JAK-STAT Pathway.
Pengfei Li,Zixiang Zhu,Xiangle Zhang,Dang Wen,Li Linlin,Xiaoli Du,Miaotao Zhang,Chunyan Wu,Qinghong Xue,Xiangtao Liu,Haixue Zheng,Yuchen Nan +11 more
TL;DR: This study revealed a new mechanism employed by PPRV to evade host innate immune response, providing a platform to study the interaction of paramyxoviruses and host response.
25
The pseudoknot region of the 5′ untranslated region is a determinant of viral tropism and virulence of foot-and-mouth disease virus.
Zixiang Zhu,Fan Yang,Weijun Cao,Huanan Liu,Keshan Zhang,Tian Hong,Dang Wen,Jijun He,Jianhong Guo,Xiangtao Liu,Haixue Zheng +10 more
TL;DR: The findings suggest that thePK region deletion occurred naturally in the FMDV genome and that the PK region is highly associated with viral host range and functions as a novel determinant for F MDV pathogenesis.
19
Recent Development of Ruminant Vaccine Against Viral Diseases.
TL;DR: The effects and implications of recent ruminant vaccine advances in terms of evolving microbiology, immunology, and molecular biology are discussed in this paper, where the authors examine the vaccination methods and technological platforms utilized for the animals may provide some useful insights.
4
The glycine locating at random coil of picornaviruses VP3 enhances viral pathogenicity by targeting p53 to promote apoptosis and autophagy
Ruoqing Mao,Fan Yang,Sun Dehui,Zhou Xiaoli,Zixiang Zhu,Xuan Guo,Huanan Liu,Tian Hong,Zhang Keshan,Dang Wen,Qing-Feng Wu,Xinwen Ma,Xiangtao Liu,Zheng Haixue +13 more
TL;DR: It is demonstrated that picORNaviruses induce apoptosis and autophagy to facilitate its pathogenicity and the Gly is functional site, providing novel insights into picornavirus biology.