Danfeng Guo
Zhejiang University
8 Papers
Danfeng Guo is an academic researcher from Zhejiang University. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 4, co-authored 4 publications.
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Papers
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
Lingling Jiang,Yingying Shen,Danfeng Guo,Diya Yang,Jiajun Liu,Xuefeng Fei,Yunshan Yang,B.X. Zhang,Zhendong Lin,Fei Yang,Xiaojian Wang,Keyi Wang,Jianli Wang,Zhijian Cai +13 more
TL;DR: The authors show that extracellular vesicles released from intestinal epithelial cells stimulate T regulatory cells and immunosuppressive dendritic cells, indicating that EVs from IECs participate in maintaining the intestinal tract immune balance.
Exosomes from heat‐stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL‐6
TL;DR: These results demonstrate that HS‐TEXs possess a powerful capacity to convert immunosuppressive Tregs into Th17 cells via IL‐6, which contributes to their potent antitumour effect.
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Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Yingying Shen,Danfeng Guo,Lixia Weng,Shoujie Wang,Zeyu Ma,Yunshan Yang,Pingli Wang,Jianli Wang,Zhijian Cai +8 more
TL;DR: In addition to the activation of DCs, TEXs induce DCs to produce increased interleukin-6 (IL-6), which dramatically promotes tumor invasion by increasing signal transducer and activator of transcription 3-dependent matrix metalloproteinases 9 transcription activity in tumor cells.
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Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1
Jiming Chen,Jie-Zuan Yang,Wenhui Wang,Danfeng Guo,Chengyan Zhang,Shibo Wang,Xinliang Lu,Xiaofang Huang,Pingli Wang,Gensheng Zhang,Jing Zhang,Jianli Wang,Zhijian Cai +12 more
TL;DR: In this article , the authors show that PD-L1 + tumor-derived extracellular vesicles (TEVs) cause systemic immunosuppression and possibly resistance to anti-PDL1 antibody (αPD-L 1) blockade.
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner.
Xiang Bo Kong,Xinliang Lu,Shibo Wang,Jiayue Hao,Danfeng Guo,Hao Wu,Yu Jiang,Yi Sun,Jianli Wang,Gensheng Zhang,Zhijian Cai +10 more
TL;DR: In this article , a negative feedback loop of IFN-I signaling was revealed and a reagent was developed to improve innate immunity against RNA viruses. But, the mechanism for IFNI signaling self-regulation is still largely unknown.
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