Dandan Li
Sichuan University
6 Papers
Dandan Li is an academic researcher from Sichuan University. The author has contributed to research in topics: Metastasis & Colorectal cancer. The author has an hindex of 6, co-authored 6 publications.
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Papers
Uric Acid Induces Cognitive Dysfunction through Hippocampal Inflammation in Rodents and Humans.
Xiaoni Shao,Wenjie Lu,Fabao Gao,Dandan Li,Jing Hu,Yan Li,Zeping Zuo,Hui Jie,Yinglan Zhao,Xiaobo Cen +9 more
TL;DR: It is shown that a high-UA diet triggers the expression of proinflammatory cytokines, activates the Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB pathway, and increases gliosis in the hippocampus of Wistar rats, suggesting that UA can cause hippocampal inflammation via the TLR4/NF-κB pathways, resulting in cognitive dysfunction.
AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model
Qin Jie Wu,Chang Yang Gong,Shun Tao Luo,Dong-Mei Zhang,Shuang Zhang,Hua Shan Shi,Lian Lu,Heng Xiu Yan,Sha Sha He,Dandan Li,Li Yang,Xia Zhao,Yu Quan Wei +12 more
TL;DR: Evaluating the ability of AAV-mediated human PEDF (hPEDF) as a potent tumor suppressor and a potential candidate for cancer gene therapy suggests that rAAV2-hP EDF may be a possible candidate as an antiangiogenic therapy agent.
Cocaine modifies brain lipidome in mice.
Yiyun Lin,Hui Gu,Linhong Jiang,Wei Xu,Chunqi Liu,Yan Li,Xinying Qian,Dandan Li,Zhuoling Li,Jing Hu,Huaqin Zhang,Wei Guo,Wei Guo,Yinglan Zhao,Xiaobo Cen +14 more
TL;DR: The results show that cocaine can markedly modify brain lipidomic profiling and reveal a link between the modified lipidome and psychopharmacological effect of cocaine, providing a new insight into the mechanism of cocaine addiction.
Tissue metabolic profiling of human gastric cancer assessed by 1 H NMR
Huijuan Wang,Huijuan Wang,Hailong Zhang,Hailong Zhang,Pengchi Deng,Chunqi Liu,Dandan Li,Hui Jie,Hu Zhang,Zong-Guang Zhou,Yinglan Zhao +10 more
TL;DR: The metabolic profiling of tissue samples on a large cohort of human gastric cancer subjects and normal controls based on 1H nuclear magnetic resonance together with multivariate statistical analyses showed robust diagnostic power of the OPLS-DA model, suggesting its great potential in detecting this disease and understanding its underlying metabolic mechanisms.
1H-NMR-based metabolic profiling of a colorectal cancer CT-26 lung metastasis model in mice.
Yan Li,Chunting Wang,Dandan Li,Pengchi Deng,Xiaoni Shao,Jing Hu,Chunqi Liu,Hui Jie,Yiyun Lin,Zhuoling Li,Xinying Qian,Huaqin Zhang,Yinglan Zhao +12 more
TL;DR: The findings indicated that the metabolite disturbance may be associated with the progression of lung metastasis from colon cancer and may be potential biomarkers that provide a promising molecular approach for clinical diagnosis and mechanistic study of colorectal cancer with Lung metastasis.