Dana Vardeman
St. Joseph Hospital
21 Papers
219 Citations
Dana Vardeman is an academic researcher from St. Joseph Hospital. The author has contributed to research in topics: Camptothecin & Chemistry. The author has an hindex of 10, co-authored 21 publications.
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Papers
Alkyl Esters of Camptothecin and 9-Nitrocamptothecin: Synthesis, in Vitro Pharmacokinetics, Toxicity, and Antitumor Activity
Zhisong Cao,Nick Harris,Anthony J. Kozielski,Dana Vardeman,John S. Stehlin,Beppino C. Giovanella +5 more
TL;DR: The in vitro pharmacokinetic determination of lactone levels of esters 6a and 7b showed that the biological life span of their lactone forms in human and mouse plasma significantly increased when compared with their mother compounds, camptothecin (3) and 9-nitrocampthecin (4).
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Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene.
Beppino C. Giovanella,Dana Vardeman,L. J. Williams,D. Jane Taylor,Peter D. de Ipolyi,Pierre J. Greeff,John S. Stehlin,Axel Ullrich,Relda Cailleau,Dennis J. Slamon,Howard E. Gary +10 more
TL;DR: Sixteen primary infiltrating duct‐cell carcinomas (PIDC) took, in striking contrast to the >50% rate of takes of most major cancers of epithelial origin, and it is possible that the nude mouse is more susceptible to a population of highly invasive and lethal breast carcinomas.
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Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan).
Beppino C. Giovanella,John S. Stehlin,Hellmuth R. Hinz,Anthony J. Kozielski,Nick Harris,Dana Vardeman +5 more
TL;DR: It appears that rubitecan is a very promising anticancer drug with high potency against a wide spectrum of human cancers.
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Structure‐Activity Relationship of Alkyl Camptothecin Esters
Zhisong Cao,Panayotis Fantazis,John Mendoza,Janet Early,A. J. Kozielski,Nick Harris,Dana Vardeman,Joachim G. Liehr,John S. Stehlin,Beppino C. Giovanella +9 more
TL;DR: Estate 2 is a prodrug of the antitumor compound CPT, and it can be administered at very high doses in mice with no appearance of toxicity, and in vivo studies showed that ester 2 had an exceptional lack of toxicity in nude mice, even at enormous doses.
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Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma.
TL;DR: A simple and sensitive high-performance liquid chromatography assay for the analysis of CZ48, a potent anticancer candidate, and its active metabolite camptothecin (CPT) in mouse plasma was developed and validated and confirmed by the determination of plasma samples in the mice after oral administration of Cz48.
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