Dana T. Graves
University of Pennsylvania
227 Papers
1.9K Citations
Dana T. Graves is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 74, co-authored 215 publications. Previous affiliations of Dana T. Graves include University of California, San Francisco & University of Texas Health Science Center at San Antonio.
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Papers
Fibroblasts, Mononuclear Phagocytes, and Endothelial Cells Express Monocyte Chemoattractant Protein-1 (MCP-1) in Inflamed Human Gingiva
Xiaohui Yu,Dana T. Graves +1 more
TL;DR: The finding that MCP-1 expression is unambiguously identified in fibroblasts suggests that they can play a role in host defense by initiating the recruitment of monocytes, and may represent a mechanism for amplification of inflammatory signals in gingival inflammation.
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Expression of monocyte chemoattractant protein 1 in human inflamed gingival tissues.
TL;DR: The finding that M CP-1 is expressed in inflamed gingival tissue suggests that MCP-1 plays an important role in the recruitment of monocytes and amplification of inflammatory signals in bacterially induced inflammation.
82
•Journal Article
Evidence that a human osteosarcoma cell line which secretes a mitogen similar to platelet-derived growth factor requires growth factors present in platelet-poor plasma.
TL;DR: The data are consistent with the hypothesis that these osteosarcoma-derived cells have growth factor requirements similar to those of normal mesenchymal cells but are able to overcome the normal growth limitations by autocrine secretion of PDGF-like mitogens.
82
•Journal Article
A Complex Element Regulates IFN-γ-Stimulated Monocyte Chemoattractant Protein-1 Gene Transcription
Anthony J. Valente,Jing Feng Xie,Margaret A. Abramova,Ulrich Wenzel,Hanna E. Abboud,Dana T. Graves +5 more
TL;DR: It is determined that IFN-gamma-enhanced MCP-1 transcription is regulated by a 29-bp element located at -227 relative to the ATG start codon, and this element is termed the IFN response-inhibitory sequence (IRIS).
81
•Journal Article
Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse.
TL;DR: The results suggest that monocytes have different functional roles in areas of bone formation compared with bone resorption and expression of MCP-1 is developmentally regulated and may provide a mechanistic basis to explain the recruitment of monocytic cells.
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