Dan Xu
Northwestern University
13 Papers
2 Citations
Dan Xu is an academic researcher from Northwestern University. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Dan Xu include Children's Memorial Hospital.
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Papers
Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy
Dan Xu,Andrew P. Robinson,Toshiyuki Ishii,Toshiyuki Ishii,D’Anne S. Duncan,Tord D. Alden,Gwendolyn E. Goings,Igal Ifergan,Joseph R. Podojil,Pablo Penaloza-MacMaster,Jennifer A. Kearney,Geoffrey T. Swanson,Stephen D. Miller,Sookyong Koh +13 more
TL;DR: In this article, the authors show a major pathological role for peripherally derived innate and adaptive proinflammatory immune responses in the pathogenesis of intractable epilepsy and suggest testing of immunomodulatory therapies.
Immune mechanisms in epileptogenesis.
TL;DR: The critical role of brain-resident immune mediators is highlighted and the proposed possible immune mechanisms that underlie epileptogenesis are proposed, including the interleukin-1 receptor/toll-like receptor signaling cascade, the pathways activated by damage-associated molecular patterns, and the cyclooxygenase-2/prostaglandin pathway.
Tolerogenic Ag-PLG Nanoparticles Induce Tregs to Suppress Activated Diabetogenic CD4 and CD8 T Cells
Suchitra Prasad,Tobias Neef,Dan Xu,Joseph R. Podojil,Daniel R. Getts,Lonnie D. Shea,Stephen D. Miller +6 more
TL;DR: The ability of carboxylated 500 nm biodegradable poly(lactide-co-glycolide) nanoparticles PLG nanoparticles (either surface coupled with or encapsulating the cognate diabetogenic peptides) to rapidly and efficiently restore tolerance in NOD is demonstrated.
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γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis.
Sarah E. Blink,Matthew W. Caldis,Gwendolyn E. Goings,Christopher T. Harp,Bernard Malissen,Immo Prinz,Dan Xu,Stephen D. Miller +7 more
TL;DR: In this paper, the authors examined distinct γδ T cell subsets during EAE and indicated they mediate differential functions in CNS inflammation and demyelination resulting in pathogenesis or protection.
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Intravenous immune-modifying nanoparticles as a therapy for spinal cord injury in mice.
Su Ji Jeong,John G. Cooper,Igal Ifergan,Tammy L. McGuire,Dan Xu,Zoe Hunter,Sripadh Sharma,Derrick P. McCarthy,Stephen D. Miller,John A. Kessler +9 more
TL;DR: The findings implicate early-infiltrating hematogenous monocytes as highly selective contributors to fibrosis that do not play an indispensable role in gliosis after SCI and suggest that the nanoparticles potentially offer a practical treatment for human spinal cord injury.
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