Cancer a Comprehensive Treatise 2

Metabolism of chemical carcinogens

Effect of phenobarbital and 3-methylcholanthrene administration on epoxide hydrase levels in liver microsomes.

Supplementary to HPLC, capillary gas chromatography (CGC) can be used in combination with mass spectrometry (MS) for the characterization and identification of polycyclic aromatic hydrocarbon (PAH) metabolites f rom various biological systems. The main advantage of this technique can be seen in (a) the high resolution of CGC which is superior to HPLC, (b) the predictability of response factors according to the dependence of the FID-signals on the carbon content , and (3) the far-reaching and readily obtainable information on the structure of metabolites by MS. A disadvantage is that volatility of the metabolites is required and that extremely polar compounds (such as glucuronides, sulfates, etc.) cannot be analyzed by this method. These problems can be partially overcome by derivatizing the metabolites.

Capillary Gas Chromatographical Analysis and Mass Spectrometric Identification of Polycyclic Aromatic Hydrocarbon Metabolites from Biological Materials

Summary The specific activity of epoxide hydrase was determined in rat liver both during development from the fetal to the adult stage and after partial hepatectomy. Hepatic enzyme activity was barely detectable in fetuses and 1-day-old neonates; it rose rapidly to the adult value by 25 days of age. Hepatic epoxide hydrase was reduced to 68% of control values by 48 hr after partial hepatectomy. The enzyme activity was markedly inhibited by 1,1,1-trichloropropene oxide.

Hepatic epoxide hydrase in neonatal and partially hepatectomized rats.

Gas chromatographic separation of the K-region epoxide and of the cis-and trans-11,12-diol derivatives of 3-methylcholanthrene.

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Gas chromatographic separation of the K-region epoxide and of the cis-and trans-11,12-diol derivatives of 3-methylcholanthrene.