Dan Groff
Scripps Research Institute
22 Papers
140 Citations
Dan Groff is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Amino acid & Genetic code. The author has an hindex of 14, co-authored 22 publications. Previous affiliations of Dan Groff include Lawrence Berkeley National Laboratory & Joint BioEnergy Institute.
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Papers
A facile system for encoding unnatural amino acids in mammalian cells
TL;DR: A shuttle system has been developed to genetically encode unnatural amino acids in mammalian cells using aminoacyl-tRNA synthetases (aaRSs) evolved in E. coli, making possible the selective incorporation of this unnatural amino acid into proteins.
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The Incorporation of a Photoisomerizable Amino Acid into Proteins in E. coli
TL;DR: It is shown that AzoPhe can be used to photoregulate the binding affinity of catabolite activator protein to its promoter and to regulate a variety of biological processes with light, including enzyme, receptor, and ion channel activity.
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Evolution of proteins with genetically encoded "chemical warheads".
Chang C. Liu,Antha V. Mack,Eric M. Brustad,Jeremy H. Mills,Dan Groff,Vaughn V. Smider,Peter G. Schultz +6 more
TL;DR: This work demonstrates that a "synthetic" genetic code can confer a selective advantage by increasing the number of functional groups available to evolution and represents a first step in the evolution of carbohydrate-binding proteins that use a reactive unnatural amino acid "warhead".
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A Genetically Encoded ε-N-Methyl Lysine in Mammalian Cells
TL;DR: To better understand the functional consequences of lysine methylation, methods are needed to generate proteins with defined methylation status both in vitro and in living cells.
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