Dan Chen
Tianjin Medical University
12 Papers
43 Citations
Dan Chen is an academic researcher from Tianjin Medical University. The author has contributed to research in topics: Growth factor receptor & Tumor microenvironment. The author has an hindex of 9, co-authored 12 publications.
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Papers
Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology.
Li Gao,Xiao-Dong Wang,Yang-Yang Niu,Yang-Yang Niu,Dan-Dan Duan,Xue Yang,Xue Yang,Jian Hao,Jian Hao,Cui-Hong Zhu,Cui-Hong Zhu,Dan Chen,Ke-xin Wang,Xue-Mei Qin,Xiong-Zhi Wu +14 more
TL;DR: Traditional Chinese medicine (TCM) has been used to treat tumors for years and has been demonstrated to be effective but the underlying molecular mechanisms of herbs remain unclear, and network pharmacology method was utilized to construct the active ingredient-target networks of herbs that were responsible for the beneficial effects against HCC.
Structural characterization and anti-tumor effects of an inulin-type fructan from Atractylodes chinensis
TL;DR: The in vitro antitumor activity of ACPS-1 was evaluated on four human cancer cell lines and showed that it could significantly inhibit Hela, HepG2, and 7721 cell proliferation, especially HepG 2, for which the fructan showed a proliferative inhibition rate as high as 87.40%.
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Molecular targets of Chinese herbs: a clinical study of metastatic colorectal cancer based on network pharmacology.
TL;DR: Bioinformatics analysis indicated that the 18 herbs realize anti-CRC activity mainly through suppressing the proliferative activity of ERBB2, peroxisome proliferator-activated receptor gamma, and retinoid X receptor, suppressing angiogenesis via inhibition of VEGFR and VEGFA expression, and inhibiting the phosphatidylinositol-3-kinase/AKT1 signaling pathway directly through SRC and AKT1.
Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells.
Jing Liang,Xiao‐Lan Zhang,Jin-Wei Yuan,Hao-Ran Zhang,Dan Liu,Jian Hao,Wei Ji,Xiong-Zhi Wu,Dan Chen +8 more
TL;DR: It is shown that low‐dose CuB inhibited adhesion and altered the viscoelasticity of breast cancer cells, thereby, reducing cell deformability and proving that CuB has been proven to mediate the reorganization and distribution of cytoskeletal proteins of breast Cancer cells through RAC1/CDC42/RhoA signaling.
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Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells
Xiu-Li Ding,Jiadong Chi,Xue Yang,Jian Hao,Chang Liu,Cui-Hong Zhu,Xiaodong Wang,Xiao-Hui Liu,Yang-Yang Niu,Wei Ji,Dan Chen,Xiong-Zhi Wu +11 more
TL;DR: Cucurbitacin B synergistically enhances the apoptosis-inducing effect of ATO by inhibiting STAT3 phosphorylation in Ramos cells, which exhibited significant apoptosis induction and tumor growth inhibition in nude murine lymphoma model.
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