Damian J. Krysan
Roy J. and Lucille A. Carver College of Medicine
146 Papers
415 Citations
Damian J. Krysan is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Candida albicans & Biology. The author has an hindex of 34, co-authored 117 publications. Previous affiliations of Damian J. Krysan include University of Michigan & University of Iowa.
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Papers
<i>FKS1</i> is required for <i>Cryptococcus neoformans</i> fitness <i>in vivo</i>: application of copper-regulated gene expression to mouse models of cryptococcosis
Damian J. Krysan,Damian J. Krysan +1 more
- 25 Mar 2022
TL;DR: In this article , the authors showed that CTR4 expression is low in the lung and high in the brain, establishing the basic premise behind this approach and applied it to the study of FKS1 , the gene encoding for the target of the echinocandin class of 1,3-β-glucan synthase inhibitors.
Cool Tools 3: Large-Scale Genetic Interaction Screening in Candida albicans
Yeissa Chabrier-Roselló,Anuj Kumar,Damian J. Krysan +2 more
- 01 Jan 2012
TL;DR: This chapter discusses the development of a novel strategy for large-scale synthetic genetic analysis in C. albicans based on complex haploin-sufficiency (CHI), which confirmed the ability of CHI to identify interacting pairs of genes and genes with similar cellular functions.
Abstract 4881: Anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition
TL;DR: Vanneste et al. as discussed by the authors evaluated the anti-cancer efficacy of a novel PTZ analog (CWHM-974), a N-benzyl-linked fluphenazine (FLU) derivative, originally developed to treat brain-resident fungal infections, and found that it is 2-10-fold more potent than FLU in a broad panel of cancer cell lines.