Dalibor Breznan
Health Canada
26 Papers
90 Citations
Dalibor Breznan is an academic researcher from Health Canada. The author has contributed to research in topics: Chemistry & A549 cell. The author has an hindex of 13, co-authored 21 publications.
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Papers
Cytotoxic and Inflammatory Potential of Size-Fractionated Particulate Matter Collected Repeatedly Within a Small Urban Area
Errol M. Thomson,Dalibor Breznan,Subramanian Karthikeyan,Christine MacKinnon-Roy,Jean-Pierre Charland,Ewa Dabek-Zlotorzynska,Valbona Celo,Prem Kumarathasan,Jeffrey R. Brook,Renaud Vincent +9 more
TL;DR: The data show that particle potency and composition can exhibit significant temporal variation in relation to source contributions; 2) sources may differentially impact the potency of specific size fractions; and 3) particle constituents, notably metals and endotoxin, may elicit distinct biological responses.
Synthesis and physicochemical characterization of mesoporous SiO 2 nanoparticles
Dharani Das,Yong Yang,Julie S. O’Brien,Dalibor Breznan,Surendra Nimesh,Stéphane Bernatchez,Myriam Hill,Abdelhamid Sayari,Renaud Vincent,Prem Kumarathasan +9 more
TL;DR: In this paper, the authors synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm and analyzed their morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media.
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Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources.
Errol M. Thomson,Dalibor Breznan,Subramanian Karthikeyan,Christine MacKinnon-Roy,Ngoc Q. Vuong,Ewa Dabek-Zlotorzynska,Valbona Celo,Jean-Pierre Charland,Prem Kumarathasan,Jeffrey R. Brook,Renaud Vincent +10 more
TL;DR: Industrial sources produce particulate emissions with varying chemical composition that differ in their in vitro potency in relation to particle size and the levels of specific constituents, and showed that particles of similar composition tended to cluster together.
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Non-specific interaction of carbon nanotubes with the resazurin assay reagent: impact on in vitro assessment of nanoparticle cytotoxicity.
Dalibor Breznan,Dharani Das,Christine MacKinnon-Roy,Benoit Simard,Premkumari Kumarathasan,Renaud Vincent +5 more
TL;DR: It is found that polar CNTs could decrease the fluorescence signal for resorufin, possibly through oxidation to resazurin or hyper-reduction to hydroxyresoruf in, which can be easily quantified for elimination of the bias.
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Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro
Dalibor Breznan,Dharani D. Das,Christine MacKinnon-Roy,Stéphane Bernatchez,Abdelhamid Sayari,Myriam Hill,Renaud Vincent,Prem Kumarathasan +7 more
TL;DR: It is indicated that newly synthesized mesoporous silica mSiNPs are less bioactive than the nonporous reference SiNP, and the integrated multilevel toxicity assessment approach can be valuable as a hazard screening tool for safety evaluations of emerging nanomaterials for regulatory purpose.
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