Dali Yin
Peking Union Medical College
38 Papers
170 Citations
Dali Yin is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Catalysis & One-pot synthesis. The author has an hindex of 11, co-authored 38 publications.
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Papers
Highly Efficient and Versatile Synthesis of Lactams and N-Heterocycles via Al(OTf)3-Catalyzed Cascade Cyclization and Ionic Hydrogenation Reactions
TL;DR: P Pyrrolindinones, piperidones, and structurally related heterocycles were formed by Al(OTf)3-catalyzed cascade cyclization and ionic hydrogenation reactions of corresponding nitrogen substituted ketoamides in good yields.
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Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis.
TL;DR: It is found that Syl930 can activate and internalize S1P1 receptors and effectively decreased the periphery blood lymphocytes (PBL) in SD rats, and subsequently rendered PBL insensitive to egress signal from secondary lymphoid organs (SLO).
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Synthesis and biological evaluation of taxinine analogues as orally active multidrug resistance reversal agents in cancer
TL;DR: In vivo studies with V CR-resistant KB/V tumor xenografts showed that compound 9 in combination with VCR significantly inhibited tumor growth, and results reveal that three taxinine analogues are good modifiers of MDR in tumor cells.
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Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action
Yi Zhang,Hongyan Li,Hongbo Wang,Fuqin Su,Runjiang Qu,Dali Yin,Jungui Dai,Yan Li,Xiaoguang Chen +8 more
TL;DR: Syl611 is an effective and potential agent in reversing multidrug resistance (MDR) by multiple actions, which attributed to p-glycoprotein inhibition and drug permeability enhancement.
18
Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents.
TL;DR: A novel series of diaryl ureas containing different linker groups demonstrated broad-spectrum antitumor activity with IC50 values of 5.17-6.46 μM against five tested tumor cell lines, representing a promising lead for further optimization.
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