Dale L. Ludwig
Eli Lilly and Company
101 Papers
820 Citations
Dale L. Ludwig is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Cancer & Antibody. The author has an hindex of 37, co-authored 101 publications. Previous affiliations of Dale L. Ludwig include Los Alamos National Laboratory & Memorial Sloan Kettering Cancer Center.
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Papers
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
Kathryn E. O'Reilly,Fredi Rojo,Qing-Bai She,David B. Solit,Gordon B. Mills,Debra G. Smith,Heidi Lane,Francesco Hofmann,Daniel J. Hicklin,Dale L. Ludwig,José Baselga,Neal Rosen +11 more
TL;DR: The data suggest that feedback down-regulation of receptor tyrosine kinase signaling is a frequent event in tumor cells with constitutive mTOR activation, and reversal of this feedback loop by rapamycin may attenuate its therapeutic effects, whereas combination therapy that ablates mTOR function and prevents Akt activation may have improved antitumor activity.
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•Journal Article
A Fully Human Monoclonal Antibody to the Insulin-Like Growth Factor I Receptor Blocks Ligand-Dependent Signaling and Inhibits Human Tumor Growth in Vivo
Douglas Burtrum,Zhenping Zhu,Dan Lu,Donna Marie Anderson,Marie Prewett,Daniel S. Pereira,Rajiv Bassi,Rashed Abdullah,Andrea T. Hooper,Henry Koo,Xenia Jimenez,Danielle P. Johnson,Robin Apblett,Paul Kussie,Peter Bohlen,Larry Witte,Daniel J. Hicklin,Dale L. Ludwig +17 more
TL;DR: Results demonstrate that A12 possesses strong antitumor activity in vitro and in vivo and may therefore be an effective therapeutic candidate for the treatment of cancers that are dependent on IGF-IR signaling for growth and survival.
A Fully Human Recombinant IgG-like Bispecific Antibody to Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor for Enhanced Antitumor Activity
Dan Lu,Haifan Zhang,Henry Koo,James R. Tonra,Paul Balderes,Marie Prewett,Eric Corcoran,Venkata R.M. Mangalampalli,Rajiv Bassi,Deborah Anselma,Dipa Patel,Xiaoqiang Kang,Dale L. Ludwig,Daniel J. Hicklin,Peter Bohlen,Larry Witte,Zhenping Zhu +16 more
TL;DR: A recombinant human IgG-like bispecific antibody, a Di-diabody, produced using the variable regions from two antagonistic antibodies that binds to both EGFR and IGFR and effectively blocked both EGF- and IGF-stimulated receptor activation and tumor cell proliferation.
310
The DNA Repair Endonuclease XPG Binds to Proliferating Cell Nuclear Antigen (PCNA) and Shares Sequence Elements with the PCNA-binding Regions of FEN-1 and Cyclin-dependent Kinase Inhibitor p21
TL;DR: The direct physical interaction of PCNA with xeroderma pigmentosum (XP) G, a structure-specific repair endonuclease that is homologous to FEN-1, raises the possibility of a mechanistic linkage between excision and repair synthesis that is mediated by PCNA.
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Physical interaction between human rad52 and rpa is required for homologous recombination in mammalian cells
TL;DR: It is suggested that direct physical interactions between RAD52 and RPA are essential for homologous recombination in mammalian cells.
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