Dalam Ly
University Health Network
19 Papers
51 Citations
Dalam Ly is an academic researcher from University Health Network. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 11, co-authored 18 publications. Previous affiliations of Dalam Ly include Brigham and Women's Hospital & Harvard University.
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Papers
Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer.
TL;DR: Recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment are reviewed.
Bee venom processes human skin lipids for presentation by CD1a
E Bourgeois,Sumithra Subramaniam,Tan-Yun Cheng,Annemieke de Jong,Emilie Layre,Dalam Ly,Maryam Salimi,Annaliza J. Legaspi,Robert L. Modlin,Mariolina Salio,Vincenzo Cerundolo,D. Branch Moody,Graham S. Ogg +12 more
TL;DR: Bee and wasp venom generate small neoantigens via phospholipase A2 that activate human T cells via CD1a presentation.
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
Dalam Ly,Anne Kasmar,Tan Yun Cheng,Annemieke de Jong,Shouxiong Huang,Sobhan Roy,Apoorva Bhatt,Ruben P. van Summeren,John D. Altman,William R. Jacobs,Erin J. Adams,Adriaan J. Minnaard,Steven A. Porcelli,D. Branch Moody +13 more
TL;DR: CD1c tetramers loaded with a phospholipid antigen from M. tuberculosis are recognized by human T cells and are distinguished from normal T cells by the immune system.
Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms.
Jong Bok Lee,Jong Bok Lee,Mark D. Minden,Weihsu C. Chen,Elena Streck,Branson Chen,Branson Chen,Hyeonjeong Kang,Andrea Arruda,Dalam Ly,Sandy D. Der,Sohyeong Kang,Paulina Achita,Paulina Achita,Cheryl A. D'Souza,Yueyang Li,Richard W. Childs,John E. Dick,John E. Dick,Li Zhang +19 more
TL;DR: This study supports healthy donor–derived allogeneic DNTs as a therapy to treat patients with chemotherapy-resistant AML and also reveals interrelated roles of NKG2D, DNAM-1, and IFNγ in selective targeting of AML by D NTs.
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers.
Sobhan Roy,Dalam Ly,Dalam Ly,Caitlin D. Castro,Nan-Sheng Li,Andrew J. Hawk,John D. Altman,Stephen C. Meredith,Joseph A. Piccirilli,D. Branch Moody,Erin J. Adams +10 more
TL;DR: Dissection of TCR interactions with CD1c carrying foreign Ags, permissive ligands, and nonpermissive lipid ligands clarifies the molecular basis of the frequently observed but poorly understood phenomenon of mixed self- and foreign Ag reactivity in the CD1 system.
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